Evidence map›Paper›PMID 25827505›Full record

ArticleJournal of affective disorders2015

Characteristics of Bipolar I patients grouped by externalizing disorders.

Shanker Swaminathan, Daniel L Koller, Tatiana Foroud, Howard J Edenberg, Xiaoling Xuei, Alexander B Niculescu, Bipolar Genome Study (BiGS) Consortium,, John I Nurnberger

Abstract read
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In one paragraph

Article in Journal of affective disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shanker SwaminathanDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Daniel L KollerDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Tatiana ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Howard J EdenbergDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Xiaoling XueiDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Alexander B NiculescuInstitute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Bipolar Genome Study (BiGS) Consortium,
John I NurnbergerDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA; Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: jnurnber@iupui.edu.

Funding

Genomic Association Study of Bipolar DisorderR01MH078151 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 2007 to 2009
$5.5M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059534 · NIMH · WASHINGTON UNIVERSITY · PI RICE, JOHN P. · 1998 to 2007
$3.1M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059545 · NIMH · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI NURNBERGER, JOHN I · 1998 to 2007
$2.6M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059533 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MACKINNON, DEAN FREDERICK · 1998 to 2007
$2.4M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH060068 · NIMH · UNIVERSITY OF CALIFORNIA IRVINE · PI BYERLEY, WILLIAM · 1998 to 2007
$2.1M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059553 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BERRETTINI, WADE H · 1998 to 2007
$2.1M
Mapping genes that contribute to bipolar disorderZ01MH002810 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2003 to 2008
$2.0M
Collaborative Genomic Study of Bipolar DisorderR01MH059548 · NIMH · UNIVERSITY OF IOWA · PI CORYELL, WILLIAM HENRY · 1998 to 2007
$1.9M
COLLABORATIVE STUDY OF BIPOLAR DISORDERR01MH059535 · NIMH · UNIVERSITY OF CHICAGO · PI GERSHON, ELLIOT S · 1998 to 2007
$1.9M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059567 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 1998 to 2007
$1.8M
COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059556 · NIMH · RUSH UNIVERSITY MEDICAL CENTER · PI SCHEFTNER, WILLIAM A · 1998 to 2007
$1.6M
Analysis of Whole Genome Association Data for Bipolar DisorderR01MH081804 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 2007 to 2007
$155k
Intramural NIH HHS Z01 MH002810NIMH NIH HHS 1Z01MH002810-01NIMH NIH HHS MH059567NIMH NIH HHS MH078151NIMH NIH HHS MH081804NIMH NIH HHS R01 MH059533NIMH NIH HHS R01 MH059534NIMH NIH HHS R01 MH059535NIMH NIH HHS R01 MH059545NIMH NIH HHS R01 MH059548NIMH NIH HHS R01MH059548NIMH NIH HHS R01 MH059553NIMH NIH HHS R01 MH059556NIMH NIH HHS R01MH059556NIMH NIH HHS R01 MH059567NIMH NIH HHS R01 MH060068NIMH NIH HHS R01 MH078151NIMH NIH HHS R01 MH081804NIMH NIH HHS R01MH59533NIMH NIH HHS R01MH59545NIMH NIH HHS R01MH59567NIMH NIH HHS R01MH60068NIMH NIH HHS U01 MH46274NIMH NIH HHS U01MH46280NIMH NIH HHS U01MH46282
6 · The paper itself

Abstract

backgroundBipolar disorder co-occurs with a number of disorders with externalizing features. The aim of this study is to determine whether Bipolar I (BPI) subjects with comorbid externalizing disorders and a subgroup with externalizing symptoms prior to age 15 have different clinical features than those without externalizing disorders and whether these could be attributed to specific genetic variations.

methodsA large cohort (N=2505) of Bipolar I subjects was analyzed. Course of illness parameters were compared between an Externalizing Group, an Early-Onset Subgroup and a Non-Externalizing Group in the Discovery sample (N=1268). Findings were validated using an independent set of 1237 BPI subjects (Validation sample). Genetic analyses were carried out.

resultsSubjects in the Externalizing Group (and Early-Onset Subgroup) tended to have a more severe clinical course, even in areas specifically related to mood disorder such as cycling frequency and rapid mood switching. Regression analysis showed that the differences are not completely explainable by substance use. Genetic analyses identified nominally associated SNPs; calcium channel genes were not enriched in the gene variants identified. LIMITATIONS: Validation in independent samples is needed to confirm the genetic findings in the present study.

conclusionsOur findings support the presence of an externalizing disorder subphenotype within BPI with greater severity of mood disorder and possible specific genetic features.

Indexed as

AffectPolymorphism, Single NucleotideSocial BehaviorAdolescentAdultAgedAge of OnsetBipolar DisorderCohort StudiesComorbidityFemaleGenome-Wide Association StudyHumansMaleMiddle AgedMood DisordersBipolar disorderComorbidityEarly onsetExternalizing disordersGenome-Wide Association Study (GWAS)

Identifiers

PMID25827505
PMCPMC4433475

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.