Evidence map›Paper›PMID 25827500›Full record

ArticleSleep & breathing = Schlaf & Atmung2015

Intrarenal hemodynamic and oxidative stress in patients with obstructive sleep apnea syndrome.

L Sardo, P Palange, F Di Mario, B Barbano, A Gigante, M Mordenti, A Steffanina, M Bonini, A Amoroso, F Vaccaro and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Evaluation of Intra-Renal Stiffness in Patients with Primary Aldosteronism.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Hypoxia: The Force that Drives Chronic Kidney Disease.Clinical medicine & research · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

L SardoDepartment of Clinical Medicine, Sapienza University of Rome, Viale dell'Università 37, 00185, Rome, Italy. liboriosardo@hotmail.com.
P PalangePublic Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
F Di MarioDepartment of Clinical Medicine, Sapienza University of Rome, Viale dell'Università 37, 00185, Rome, Italy.
B BarbanoDepartment of Clinical Medicine, Sapienza University of Rome, Viale dell'Università 37, 00185, Rome, Italy.
A GiganteDepartment of Clinical Medicine, Sapienza University of Rome, Viale dell'Università 37, 00185, Rome, Italy.
M MordentiPublic Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
A SteffaninaPublic Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
M BoniniPublic Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
A AmorosoDepartment of Clinical Medicine, Sapienza University of Rome, Viale dell'Università 37, 00185, Rome, Italy.
F VaccaroPublic Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
R CianciDepartment of Clinical Medicine, Sapienza University of Rome, Viale dell'Università 37, 00185, Rome, Italy.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOxygen desaturation and reoxygenation, related to intermittent hypoxia cycles due to upper airway obstruction, are major pathophysiologic features of obstructive sleep apnea syndrome (OSAS) and are thought to be responsible for an increased risk of cardiovascular diseases. Continuous positive airway pressure (CPAP) is therefore considered the gold standard in the management of OSAS. Further data demonstrated a high prevalence of OSAS in patients with altered renal function despite the underlying pathophysiological mechanisms that have not been clarified. This study aims to provide evidence on the reported high prevalence of endothelial dysfunction and alterations of the intrarenal hemodynamic in patients affected by OSAS. Furthermore, we evaluated the effect of a CPAP therapy on these endpoints.

methodsTwenty patients were enrolled in a prospective study and underwent ultrasound examination to assess endothelial dysfunction, by collecting brachial flow-mediated dilation (FMD) and intrarenal artery stiffness, pre- and post a 30-day treatment with CPAP.

resultsEndothelial dysfunction and intrarenal artery stiffness significantly improved in all patients after a month of CPAP. In particular, we observed a significant reduction in the renal resistance index (RI) (p < 0.001) and systolic/diastolic ratio (S/D) ratio (p < 0.001) and a significant increase of FMD (p < 0.001). The apnea-hypopnea index (AHI) showed a negative correlation with Δ FMD (p < 0.05, r = -0.46). Conversely, a positive correlation exists between Δ RI and the oxygen desaturation index (ODI) (specificare la sigla) (p < 0.05, r = 0.46).

conclusionsOur study firstly showed a significant effect of CPAP on renal perfusion and endothelial function in OSAS patients without concomitant cardiovascular comorbidities.

Indexed as

AdultAgedContinuous Positive Airway PressureEndothelium, VascularFemaleHemodynamicsHome Care ServicesHumansKidneyMaleMiddle AgedOxidative StressOxygenPolysomnographyProspective StudiesRenal ArteryOxygenContinuous positive airway pressureEndothelial dysfunctionObstructive sleep apneaRenal resistance index

Identifiers

PMID25827500
OpenAlexW2090526727

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.