Evidence map›Paper›PMID 25827314›Full record

ArticleJournal of exposure science & environmental epidemiology

Effect of time-activity adjustment on exposure assessment for traffic-related ultrafine particles.

Kevin J Lane, Jonathan I Levy, Madeleine Kangsen Scammell, Allison P Patton, John L Durant, Mkaya Mwamburi, Wig Zamore, Doug Brugge

Open access · hybridAbstract read
In one paragraph

Article in Journal of exposure science & environmental epidemiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Systematic review and meta-analysis on the health effects of long-term exposure to ultrafine particles.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. Pooled it
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  12. Distributions and determinants of time spent outdoors among school-age children in China.Journal of exposure science & environmental epidemiology · 2022
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  14. Review
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  20. Viruses and non-allergen environmental triggers in asthma.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Kevin J Lane1] Yale School of Forestry and Environmental Studies, New Haven, Connecticut, USA [2] Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA.
Jonathan I LevyDepartment of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA.
Madeleine Kangsen ScammellDepartment of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA.
Allison P Patton1] Rutgers Environmental and Occupational Health Sciences Institute, Piscataway, New Jersey, USA [2] Department of Civil and Environmental Engineering, Tufts University, Medford, Massachusetts, USA.
John L DurantDepartment of Civil and Environmental Engineering, Tufts University, Medford, Massachusetts, USA.
Mkaya MwamburiDepartment of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA.
Wig ZamoreSomerville Transportation Equity Partnership, Somerville, Massachusetts, USA.
Doug BruggeDepartment of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA.
Tufts University · USBoston University · USRutgers, The State University of New Jersey · USSomerville Hospital · USYale University · US

Funding

Environmental Epidemiology in Community SettingsT32ES014562 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Birgit Gunhild Claus Henn · 2006 to 2026
$7.7M
Community Assessment of Freeway Pollution and HealthR01ES015462 · NIEHS · TUFTS UNIVERSITY BOSTON · PI BRUGGE, DOUG · 2008 to 2012
$2.5M
NIEHS NIH HHS ES015462NIEHS NIH HHS R01 ES015462NIEHS NIH HHS T32 ES014562
6 · The paper itself

Abstract

Exposures to ultrafine particles (<100 nm, estimated as particle number concentration, PNC) differ from ambient concentrations because of the spatial and temporal variability of both PNC and people. Our goal was to evaluate the influence of time-activity adjustment on exposure assignment and associations with blood biomarkers for a near-highway population. A regression model based on mobile monitoring and spatial and temporal variables was used to generate hourly ambient residential PNC for a full year for a subset of participants (n=140) in the Community Assessment of Freeway Exposure and Health study. We modified the ambient estimates for each hour using personal estimates of hourly time spent in five micro-environments (inside home, outside home, at work, commuting, other) as well as particle infiltration. Time-activity adjusted (TAA)-PNC values differed from residential ambient annual average (RAA)-PNC, with lower exposures predicted for participants who spent more time away from home. Employment status and distance to highway had a differential effect on TAA-PNC. We found associations of RAA-PNC with high sensitivity C-reactive protein and Interleukin-6, although exposure-response functions were non-monotonic. TAA-PNC associations had larger effect estimates and linear exposure-response functions. Our findings suggest that time-activity adjustment improves exposure assessment for air pollutants that vary greatly in space and time.

Indexed as

AdultAgedAir PollutantsAir PollutionBiomarkersC-Reactive ProteinCross-Sectional StudiesEnvironmental MonitoringFemaleGeographic MappingHumansInterleukin-6MaleMassachusettsMiddle AgedParticle SizeAir PollutantsBiomarkersC-Reactive ProteinInterleukin-6Particulate MatterVehicle Emissions

Identifiers

PMID25827314
PMCPMC4542140
OpenAlexW2082468958

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.