Evidence map›Paper›PMID 25827311›Full record

SynthesisJournal of exposure science & environmental epidemiology

Traffic-related air pollution exposure and incidence of stroke in four cohorts from Stockholm.

Michal J Korek, Tom D Bellander, Tomas Lind, Matteo Bottai, Kristina M Eneroth, Barbara Caracciolo, Ulf H de Faire, Laura Fratiglioni, Agneta Hilding, Karin Leander and 5 more

Abstract readMeta-Analysis
In one paragraph

Synthesis in Journal of exposure science & environmental epidemiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Air Pollution and Ischaemic Stroke.Annals of Indian Academy of Neurology · 2022
    Article
  15. Article
  16. Article
  17. Health and economic impacts from PMEnvironmental science and pollution research international · 2021
    Article
  18. Impact of Air Pollution (PMInternational journal of environmental research and public health · 2021
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Michal J KorekInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Tom D Bellander1] Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden [2] Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden.
Tomas LindCentre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden.
Matteo BottaiDivision of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Kristina M EnerothEnvironment and Health Administration, Stockholm, Sweden.
Barbara CaraccioloDepartment of Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska Institutet, Stockholm, Sweden.
Ulf H de FaireInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Laura Fratiglioni1] Department of Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska Institutet, Stockholm, Sweden [2] Stockholm Gerontology Research Center, Stockholm, Sweden [3] Division of Clinical Geriatrics, Karolinska University Hospital, Stockholm, Sweden.
Agneta HildingDepartment of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden.
Karin LeanderInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistcs, Karolinska Institutet, Stockholm, Sweden.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistcs, Karolinska Institutet, Stockholm, Sweden.
Claes-Göran ÖstensonDepartment of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden.
Göran PershagenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Johanna C PenellInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Funding

DEMENTIA IN TWINSR01AG008724 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET · 1990 to 2002
$1.4M
NIA NIH HHS AG-08724
6 · The paper itself

Abstract

We investigated the risk of stroke related to long-term ambient air pollution exposure, in particular the role of various exposure time windows, using four cohorts from Stockholm County, Sweden. In total, 22,587 individuals were recruited from 1992 to 2004 and followed until 2011. Yearly air pollution levels resulting from local road traffic emissions were assessed at participant residences using dispersion models for particulate matter (PM10) and nitrogen oxides (NOX). Cohort-specific hazard ratios were estimated for time-weighted air pollution exposure during different time windows and the incidence of stroke, adjusted for common risk factors, and then meta-analysed. Overall, 868 subjects suffered a non-fatal or fatal stroke during 238,731 person-years of follow-up. An increment of 20 μg/m(3) in estimated annual mean of road-traffic related NOX exposure at recruitment was associated with a hazard ratio of 1.16 (95% CI 0.83-1.61), with evidence of heterogeneity between the cohorts. For PM10, an increment of 10 μg/m(3) corresponded to a hazard ratio of 1.14 (95% CI 0.68-1.90). Time-window analyses did not reveal any clear induction-latency pattern. In conclusion, we found suggestive evidence of an association between long-term exposure to NOX and PM10 from local traffic and stroke at comparatively low levels of air pollution.

Indexed as

AdultAgedAged, 80 and overAir PollutantsAir PollutionCohort StudiesFemaleHumansIncidenceMaleMiddle AgedNitrogen DioxideParticle SizeParticulate MatterProportional Hazards ModelsRisk FactorsAir PollutantsNitrogen DioxideParticulate MatterVehicle Emissions

Identifiers

PMID25827311
PMCPMC4648059

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.