Evidence map›Paper›PMID 25827275›Full record

ReviewCurrent opinion in neurobiology2015

Brain-controlled neuromuscular stimulation to drive neural plasticity and functional recovery.

C Ethier, J A Gallego, L E Miller

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Neurostimulation for Stroke Rehabilitation.Frontiers in neuroscience · 2021
    Review
  16. Review
  17. Closed-Loop Neuromodulation in Physiological and Translational Research.Cold Spring Harbor perspectives in medicine · 2019
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

C EthierDepartment of Physiology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Avenue, Chicago, IL 60611 USA.
J A GallegoDepartment of Physiology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Avenue, Chicago, IL 60611 USA; Neural and Cognitive Engineering Group, Centre for Automation and Robotics, Spanish National Research Council (CSIC), Ctra. Campo Real km 0.2, Arganda del Rey, Madrid 28500 Spain.
L E MillerDepartment of Physiology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Avenue, Chicago, IL 60611 USA; Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, 345 E. Superior Avenue, Chicago, IL 60611, USA; Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA. Electronic address: lm@northwestern.edu.

Funding

Primate model of an intracortically controlled FES prostR01NS053603 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KENNEDY, ANN KATHRYN, MILLER, LEE · 2006 to 2021
$7.1M
NINDS NIH HHS NS053603NINDS NIH HHS R01 NS053603
6 · The paper itself

Abstract

There is mounting evidence that appropriately timed neuromuscular stimulation can induce neural plasticity and generate functional recovery from motor disorders. This review addresses the idea that coordinating stimulation with a patient's voluntary effort might further enhance neurorehabilitation. Studies in cell cultures and behaving animals have delineated the rules underlying neural plasticity when single neurons are used as triggers. However, the rules governing more complex stimuli and larger networks are less well understood. We argue that functional recovery might be optimized if stimulation were modulated by a brain machine interface, to match the details of the patient's voluntary intent. The potential of this novel approach highlights the need for a better understanding of the complex rules underlying this form of plasticity.

Indexed as

Brain-Computer InterfacesRecovery of FunctionAnimalsBrainElectric StimulationEvoked Potentials, MotorHumansNeuromuscular JunctionNeuronal Plasticity

Identifiers

PMID25827275
PMCPMC4523462

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.