ArticleJournal of clinical hypertension (Greenwich, Conn.)2015
Association of PPAR-γ2 and β3-AR Polymorphisms With Postmenopausal Hypertension.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association between peroxisome proliferator-activated receptor γ-2 gene Pro12Ala polymorphisms and risk of hypertension: an updated meta-analysis.Bioscience reports · 2019Pooled it
- Pooled it
- Pooled it
- The Influence ofGenes · 2023Article
- Genetic Background of Hypertension in Connective Tissue Diseases.Journal of immunology research · 2020Article
- Association between potassium channel SNPs and essential hypertension in Xinjiang Kazak Chinese patients.Experimental and therapeutic medicine · 2017Article
- The Gene-Diet Associations in Postmenopausal Women with Newly Diagnosed Dyslipidemia.The journal of nutrition, health & aging · 2017Article
- Genetic Background, Adipocytokines, and Metabolic Disorders in Postmenopausal Overweight and Obese Women.Biochemical genetics · 2016Article
- Impact of the PPAR gamma-2 gene polymorphisms on the metabolic state of postmenopausal women.Journal of biosciences · 2016Article
- Genomic Research in Postmenopausal Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2015Article
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5 authors.
Funding
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Abstract
The aim of this study was to test the association of peroxisome proliferator-activated receptor (PPAR-γ2) (Pro12Ala, C1431T) and β3-AR (Trp64Arg) polymorphisms with metabolic, nutritional, and blood pressure parameters in 271 postmenopausal women (151 hypertensive and 120 normotensive controls). The TaqMan genotyping assay and restriction fragment length polymorphism methods were used to determine the distributions of selected alleles and genotype frequencies. Nutritional status was determined by a bioimpedance method and dietary habits were assessed via 7-day dietary recall. The distribution of selected genotypes and allele frequencies did not differ between hypertensive women and normal controls after analysis by chi-square test. The postmenopausal hypertensive women were older and had higher body fat mass, serum glucose, and triglyceride levels. The cluster analysis showed that the hypertensive group with Pro12Pro genotype had highest pulse pressure and mean arterial pressure values when compared with Pro12Ala patients. In the logistic regression analysis, blood glucose (Pro12Ala polymorphism) and energy intake (C1431Tand T1431T polymorphisms) determined hypertension.
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