ArticlePloS one2015
Age-dependent sex difference of the incidence and mortality of status epilepticus: a twelve year nationwide population-based cohort study in Taiwan.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Sex and gender-related differences in neurological diseases: current challenges and recommendations for clinical practice.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- Stroboscopic light stimulation safety within and beyond laboratory settings: Observational evidence and practical guidance.PloS one · 2026Article
- Incidence, mortality, and management of status epilepticus from 2012 to 2022: An 11-year nationwide study.Epilepsia · 2026Article
- The impact of revised definitions on the epidemiology of status epilepticus: A population-based study.Epilepsia · 2025Article
- Status epilepticus: Updates on mechanisms and treatments.Epilepsia open · 2025Review
- Mortality of Epilepsy in Chinese Populations: A Comprehensive Review.Neuroepidemiology · 2025Review
- Sex-related differences in adult patients with status epilepticus: a seven-year two-center observation.Critical care (London, England) · 2023Article
- Mortality, and life expectancy in Epilepsy and Status epilepticus-current trends and future aspects.Frontiers in epidemiology · 2023Review
- [Frequency and clinico-therapeutic features of patients with status epilecticus hospitalized in the department of neurology of the Bafelatanana hospital, Antananarivo, Madagascar].The Pan African medical journal · 2022Article
- Occurrence of status epilepticus in persons with epilepsy is determined by sex, epilepsy classification, and etiology: a single center cohort study.Journal of neurology · 2021Article
- Factors Associated With Prolonged Length of Stay in Patients Hospitalized With Generalized Convulsive Status Epilepticus in the United States.The Neurohospitalist · 2021Article
- Association between telemedicine and incidence of status epilepticus during the COVID-19 pandemic.Epilepsy & behavior : E&B · 2021Article
- Epidemiology and Outcomes of Status Epilepticus.International journal of general medicine · 2021Review
- The etiology and risk factors of convulsive status epilepticus in pediatric patients of tertiary center in Saudi Arabia.Neurosciences (Riyadh, Saudi Arabia) · 2021Article
- One- to 10-year Status Epilepticus Mortality (SEM) score after 30 days of hospital discharge: development and validation using competing risks analysis.BMC neurology · 2019Article
- Epidemiology of status epilepticus in adults: A population-based study on incidence, causes, and outcomes.Epilepsia · 2019Article
- Predictors of hospital and one-year mortality in intensive care patients with refractory status epilepticus: a population-based study.Critical care (London, England) · 2017Article
- Article
- Managing Status Epilepticus in the Older Adult.Journal of clinical medicine · 2016Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Status epilepticus (SE) is a serious neurologic emergency associated with a significant mortality. The objective of this study is to investigate its epidemiology in terms of age- and sex-specific incidences and mortality. By using the Taiwan National Health Insurance Research Database during 2000 to 2011, we identified hospitalized patients with a discharged diagnosis of SE and calculated the incidence and in-hospital mortality of SE with respect to age and sex. The overall incidence of SE was 4.61 per 100,000 person-years, which displayed a "J-shaped" distribution by age with a little higher under the age of 5 and highest over 60 years. The male-to-female rate ratio was 1.57 and it demonstrated a "mountain-shape" across ages with the peak at 45 to 49 years old. The in-hospital mortality was significantly lower in males (7.38%) than in females (11.12%) with an odds ratio of 0.64 (95% CI 0.56-0.72). Notably, the in-hospital mortality for females increased rapidly after the age of 40 to 45 years. The multivariate analysis found males had a significantly lower risk of mortality than females after, but not before, 45 years of age with an odds ratio of 0.56 (95% CI 0.49-0.65). Sex and age are crucial factors associated with the incidence and in-hospital mortality of SE. The females over 45 years of age have a higher risk of occurrence and mortality from SE. The underlying mechanism deserves further study.
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