Trial reportPloS one2015
Diarrhea, stimulation and growth predict neurodevelopment in young North Indian children.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Early life risk factors of motor, cognitive and language development: a pooled analysis of studies from low/middle-income countries.BMJ open · 2019Pooled it
- Participation in a Community-Based Women's Health Education Program and At-Risk Child Development in Rural Kenya: Developmental Screening Questionnaire Results Analysis.Global health, science and practice · 2021Trial
- Trial
- Early-Life Exposures, Neurodevelopment, and Health Outcomes: Protocol for a Birth Cohort Study.JMIR research protocols · 2026Article
- Watery diarrhea in early childhood and neuro-cognitive development: longitudinal follow-up study in Bangladesh.Frontiers in public health · 2026Article
- The relationship between the ages and stages questionnaire, 3rd edition scores in early childhood and future cognitive abilities in young Nepalese children.BMC pediatrics · 2024Article
- Measuring early child development across low and middle-income countries: A systematic review.Journal of early childhood research : ECR · 2021Article
- Modeling Enteropathy or Diarrhea with the Top Bacterial and Protozoal Pathogens: Differential Determinants of Outcomes.ACS infectious diseases · 2021Review
- Factors determining cognitive, motor and language scores in low birth weight infants from North India.PloS one · 2021Article
- Agreement Between Mothers and Fieldworkers While Assessing Child Development Using Ages and Stages Questionnaires, Third Edition in Nepal.Frontiers in psychology · 2020Article
- Review
- Determinants of Cognitive Development in the Early Life of Children in Bhaktapur, Nepal.Frontiers in psychology · 2019Article
- Vitamin-D status and neurodevelopment and growth in young north Indian children: a secondary data analysis.Nutrition journal · 2017Article
- Does Measles Vaccination Reduce the Risk of Acute Respiratory Infection (ARI) and Diarrhea in Children: A Multi-Country Study?PloS one · 2017Article
- Interactions between intestinal pathogens, enteropathy and malnutrition in developing countries.Current opinion in infectious diseases · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
BACKGROUND AND
objectiveInfants and young children in low to middle-income countries are at risk for adverse neurodevelopment due to multiple risk factors. In this study, we sought to identify stimulation and learning opportunities, growth, and burden of respiratory infections and diarrhea as predictors for neurodevelopment.
methodsWe visited 422 North Indian children 6 to 30 months old weekly for six months. Childhood illnesses were assessed biweekly. At end study, we assessed neurodevelopment using the Ages and Stages Questionnaire 3rd ed. (ASQ-3) and gathered information on stimulation and learning opportunities. We identified predictors for ASQ-3 scores in multiple linear and logistic regression models.
resultsWe were able to explain 30.5% of the variation in the total ASQ-3 score by the identified predictors. When adjusting for child characteristics and annual family income, stimulation and learning opportunities explained most of the variation by 25.1%. Height for age (standardized beta: 0.12, p<.05) and weight for height z-scores (std. beta: 0.09, p<.05) were positively associated with the total ASQ-3 score, while number of days with diarrhea was negatively associated with these scores (std. beta: -0.13, p<0.01).
conclusionOur results support the importance of early child stimulation and general nutrition for child development. Our study also suggests that diarrhea is an additional risk factor for adverse neurodevelopment in vulnerable children.
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