ArticleDepression and anxiety2015
Reward learning in pediatric depression and anxiety: preliminary findings in a high-risk sample.
Article in Depression and anxiety, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Pooled it
- Targeting positive valence systems function in children of mothers with depressive symptoms: A pilot randomized trial of an RDoC-Informed preventive intervention.Behaviour research and therapy · 2023Trial
- Positive affect treatment targets reward sensitivity: A randomized controlled trial.Journal of consulting and clinical psychology · 2023Trial
- A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia.Nature medicine · 2020Trial
- Letting Go of the Negative, Holding on to the Positive? Within-Person Trajectories of Affective Habituation to Negative and Positive Stimuli.Personality & social psychology bulletin · 2026Article
- Probing biomarkers and clinical utility of reward learning across species using the Probabilistic Reward Task: 20 years of findings.Nature. Mental health · 2026Article
- Reward-specific learning parameters change across normative adolescent development and are blunted in youth with high risk for depression.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Reward Processing in Mood Disorders and Schizophrenia: A Neurodevelopmental Framework.Annual review of clinical psychology · 2025Review
- Reinforcement Learning and Decision Making in Depression in Adolescents and Young Adults: Insights from a New Model of the Probabilistic Reward Task.Computational psychiatry (Cambridge, Mass.) · 2025Article
- Cross-species translational paradigms for assessing positive valence system as defined by the RDoC matrix.Journal of neurochemistry · 2025Review
- Electrical brain activations in preadolescents during a probabilistic reward-learning task reflect cognitive processes and behavior strategies.Frontiers in human neuroscience · 2025Article
- Using Inhibitory Learning Theories to Optimise Treatment for Children with Anxiety Disorders.Current topics in behavioral neurosciences · 2025Review
- Beta activity in human anterior cingulate cortex mediates reward biases.Nature communications · 2024Article
- Annual Research Review: Neuroimmune network model of depression: a developmental perspective.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
- Neural activation and connectivity in offspring of depressed mothers during monetary and social reward tasks.Biological psychology · 2024Article
- Does reward processing moderate or mediate the link between childhood adversity and psychopathology: A longitudinal study.Development and psychopathology · 2023Article
- Structural equation modeling of treatment-related changes in neural connectivity for youth with PTSD.Journal of affective disorders · 2023Article
- Reward Behavior Disengagement, a Neuroeconomic Model-Based Objective Measure of Reward Pathology in Depression: Findings from the EMBARC Trial.Behavioral sciences (Basel, Switzerland) · 2023Article
- Probabilistic Reinforcement Learning and Anhedonia.Current topics in behavioral neurosciences · 2022Article
- Neural Responses to Social Reward Predict Depressive Symptoms in Adolescent Girls During the COVID-19 Pandemic.Journal of pediatric psychology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundReward learning has been postulated as a critical component of hedonic functioning that predicts depression risk. Reward learning deficits have been established in adults with current depressive disorders, but no prior studies have examined the relationship of reward learning and depression in children. The present study investigated reward learning as a function of familial depression risk and current diagnostic status in a pediatric sample.
methodThe sample included 204 children of parents with a history of depression (n = 86 high-risk offspring) or parents with no history of major mental disorder (n = 118 low-risk offspring). Semistructured clinical interviews were used to establish current mental diagnoses in the children. A modified signal detection task was used for assessing reward learning. We tested whether reward learning was impaired in high-risk offspring relative to low-risk offspring. We also tested whether reward learning was impaired in children with current disorders known to blunt hedonic function (depression, social phobia, PTSD, GAD, n = 13) compared to children with no disorders and to a psychiatric comparison group with ADHD.
resultsHigh- and low-risk youth did not differ in reward learning. However, youth with current anhedonic disorders (depression, social phobia, PTSD, GAD) exhibited blunted reward learning relative to nondisordered youth and those with ADHD.
conclusionsOur results are a first demonstration that reward learning deficits are present among youth with disorders known to blunt anhedonic function and that these deficits have some degree of diagnostic specificity. We advocate for future studies to replicate and extend these preliminary findings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.