ArticlePLoS neglected tropical diseases2015
Evaluation of inapparent dengue infections during an outbreak in Southern China.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Global Epidemiology of Dengue Outbreaks in 1990-2015: A Systematic Review and Meta-Analysis.Frontiers in cellular and infection microbiology · 2017Pooled it
- Dengue surveillance using gravid oviposition sticky (GOS) trap and dengue non-structural 1 (NS1) antigen test in Malaysia: randomized controlled trial.Scientific reports · 2022Trial
- Evaluating the effects of control interventions and estimating the inapparent infections for dengue outbreak in Hangzhou, China.PloS one · 2019Trial
- Assessing the impact of intervention strategies on dengue dynamics in Shenzhen, China.PLoS neglected tropical diseases · 2026Article
- Dengue transmission dynamics in China's border regions adjacent to Myanmar.Infectious diseases of poverty · 2026Article
- Review
- Investigation of Dengue Infection in Asymptomatic Individuals during a Recent Outbreak in La Réunion.Viruses · 2023Article
- Model-based risk assessment of dengue fever transmission in Xiamen City, China.Frontiers in public health · 2023Article
- Prior water availability modifies the effect of heavy rainfall on dengue transmission: a time series analysis of passive surveillance data from southern China.Frontiers in public health · 2023Article
- Epidemiological Characteristics and the Dynamic Transmission Model of Dengue Fever in Zhanjiang City, Guangdong Province in 2018.Tropical medicine and infectious disease · 2022Article
- Increasingly expanded future risk of dengue fever in the Pearl River Delta, China.PLoS neglected tropical diseases · 2021Article
- The increasing menace of dengue in Guangzhou, 2001-2016: the most important epicenter in mainland China.BMC infectious diseases · 2019Article
- From the threat to the large outbreak: dengue on Reunion Island, 2015 to 2018.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- Incidence dynamics and investigation of key interventions in a dengue outbreak in Ningbo City, China.PLoS neglected tropical diseases · 2019Article
- Seroepidemiology of dengue virus infection among adults during the ending phase of a severe dengue epidemic in southern Taiwan, 2015.BMC infectious diseases · 2019Article
- Risk Factors Associated with Dengue Virus Infection in Guangdong Province: A Community-Based Case-Control Study.International journal of environmental research and public health · 2019Article
- Biopesticides improve efficiency of the sterile insect technique for controlling mosquito-driven dengue epidemics.Communications biology · 2019Article
- Modeling the Heterogeneity of Dengue Transmission in a City.International journal of environmental research and public health · 2018Article
- The Epidemiology of Imported Acute Infectious Diseases in Zhejiang Province, China, 2011-2016: Analysis of Surveillance Data.The American journal of tropical medicine and hygiene · 2018Article
- Prediction of dengue outbreaks in Mexico based on entomological, meteorological and demographic data.PloS one · 2018Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Few studies evaluating inapparent dengue virus (DENV) infections have been conducted in China. In 2013, a large outbreak of DENV occurred in the city of Zhongshan, located in Southern China, which provided an opportunity to assess the clinical spectrum of disease. During the outbreak, an investigation of 887 index case contacts was conducted to evaluate inapparent and symptomatic DENV infections. Post-outbreak, an additional 815 subjects from 4 towns with, and 350 subjects from 2 towns without reported autochthonous DENV transmission, as determined by clinical diagnosis, were evaluated for serological evidence of dengue IgG antibodies. Between July and November 2013, there were 19 imported and 809 autochthonous dengue cases reported in Zhongshan. Of 887 case contacts enrolled during the outbreak, 13 (1.5%) exhibited symptomatic DENV infection, while 28 (3.2%) were inapparent. The overall I:S ratio was 2.2:1 (95% CI: 1.1-4.2:1). Post-outbreak serological data showed that the proportion of DENV IgG antibody detection from the 4 towns with and the 2 towns without reported DENV transmission was 2.7% (95% CI: 1.6%-3.8%) and 0.6% (95% CI: 0-1.4%), respectively. The I:S ratio in the 3 towns where clinical dengue cases were predominately typed as DENV-1 was 11.0:1 (95% CI: 3.7-∞:1). The ratio in the town where DENV-3 was predominately typed was 1.0:1 (95% CI: 0.5-∞:1). In this cross-sectional study, data suggests a high I:S ratio during a documented outbreak in Zhongshan, Southern China. These results have important implications for dengue control, implying that inapparent cases might influence DENV transmission more than previously thought.
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