ArticlePediatric research2015
Neutrophil and monocyte toll-like receptor 4, CD11b and reactive oxygen intermediates, and neuroimaging outcomes in preterm infants.
Article in Pediatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Is neutrophil CD11b a special marker for the early diagnosis of sepsis in neonates? A systematic review and meta-analysis.BMJ open · 2019Pooled it
- The role of persistent inflammation in failed recovery after perinatal brain injury: is resolution the cure?Journal of neuroinflammation · 2026Review
- Early immune modulation in cerebral palsy medical management of cerebral palsy series.Pediatric research · 2025Article
- Article
- Neutrophil-Mediated Delivery of Nanocrystal Drugs via Photoinduced Inflammation Enhances Cancer Therapy.ACS nano · 2023Article
- Defective Leukocyte β2 Integrin Expression and Reactive Oxygen Species Production in Neonates.Children (Basel, Switzerland) · 2022Article
- PSB0788 ameliorates maternal inflammation-induced periventricular leukomalacia-like injury.Bioengineered · 2022Article
- Burn-injured skin is marked by a prolonged local acute inflammatory response of innate immune cells and pro-inflammatory cytokines.Frontiers in immunology · 2022Article
- Sustained peripheral immune hyper-reactivity (SPIHR): an enduring biomarker of altered inflammatory responses in adult rats after perinatal brain injury.Journal of neuroinflammation · 2021Article
- Leptin Receptor q223r Polymorphism InfluencesFrontiers in cellular and infection microbiology · 2021Article
- Neutrophil CD11b as a promising marker for early detection of neonatal sepsis.Clinical and experimental pediatrics · 2021Article
- Midkine: The Who, What, Where, and When of a Promising Neurotrophic Therapy for Perinatal Brain Injury.Frontiers in neurology · 2020Review
- Dysregulated Monocyte and Neutrophil Functional Phenotype in Infants With Neonatal Encephalopathy Requiring Therapeutic Hypothermia.Frontiers in pediatrics · 2020Article
- Neutrophil activation causes tumor regression in Walker 256 tumor-bearing rats.Scientific reports · 2019Article
- Pediatric Intensive Care: Immunomodulation With Activated Protein CFrontiers in pediatrics · 2019Article
- Altered endotoxin responsiveness in healthy children with Down syndrome.BMC immunology · 2018Article
- Temporal Gene Expression Profiles after Focal Cerebral Ischemia in Mice.Aging and disease · 2018Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundActivated leukocytes and infection are implicated in neonatal brain injury. Leukocyte surface receptors are increased in stroke models and may be targets for future adjunctive therapies.
methodsSerial blood samples were analyzed from preterm infants (n = 51; <32 wk gestation) on days 0, 1, 2, and 7 of life. Monocyte and neutrophil activation were evaluated via flow cytometry at baseline and following endotoxin stimulation ex vivo by measuring CD11b (activation), toll-like receptor 4 (TLR-4; endotoxin recognition) expression, and intracellular reactive oxygen intermediate (ROI) production (function).
resultsControl preterm infants with normal neuroimaging had elevated baseline CD11b and TLR-4 expression and ROI production compared with adults as well as a robust immune response following endotoxin stimulation. Preterm infants with abnormal neuroimaging had increased neutrophil TLR-4 and ROI compared with all controls.
conclusionPreterm infants have a robust immune response compared with adults. Increased TLR-4 expression in preterm infants with abnormal neuroimaging is similar to findings in adult stroke. In addition, ROI production may cause tissue injury. The modulation of these responses may be beneficial in preterm inflammatory disorders.
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