ArticlePediatric research2015
Ontogeny of cerebrovascular critical closing pressure.
Article in Pediatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Hemodynamic Changes in the Transition Period in the Preterm and Term Infant: Basic Concepts.Turkish archives of pediatrics · 2025Article
- The prediction of estimated cerebral perfusion pressure with trans-systolic time in preterm and term infants.European journal of pediatrics · 2024Article
- Point/counterpoint: Cerebrovascular resistance is a flawed concept.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Special Anaesthetic Considerations for Brain Tumour Surgery in Children.Children (Basel, Switzerland) · 2022Review
- Cerebral Arterial Compliance in Polytraumazed Patients with Cerebral Vasospasm.Acta neurochirurgica. Supplement · 2020Article
- Cerebral Hemodynamics Are Not Affected by the Size of the Patent Ductus Arteriosus.Neonatology · 2020Article
- Beyond Anesthesia Toxicity: Anesthetic Considerations to Lessen the Risk of Neonatal Neurological Injury.Anesthesia and analgesia · 2019Review
- Neonatal cerebrovascular autoregulation.Pediatric research · 2018Review
- Noninvasive optical monitoring of critical closing pressure and arteriole compliance in human subjects.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Elevated Diastolic Closing Margin Is Associated with Intraventricular Hemorrhage in Premature Infants.The Journal of pediatrics · 2016Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundPremature infants are at risk of vascular neurologic insults. Hypotension and hypertension are considered injurious, but neither condition is defined with consensus. Cerebrovascular critical closing pressure (CrCP) is the arterial blood pressure (ABP) at which cerebral blood flow (CBF) ceases. CrCP may serve to define subject-specific low or high ABP. Our objective was to determine the ontogeny of CrCP.
methodsPremature infants (n = 179) with gestational age (GA) from 23-31 wk had recordings of ABP and middle cerebral artery flow velocity twice daily for 3 d and then daily for the duration of the first week of life. All infants received mechanical ventilation. CrCP was calculated using an impedance-model derivation with Doppler-based estimations of cerebrovascular resistance and compliance. The association between GA and CrCP was determined in a multivariate analysis.
resultsThe median (interquartile range) CrCP for the cohort was 22 mm Hg (19-25 mm Hg). CrCP increased significantly with GA (r = 0.6; slope = 1.4 mm Hg/wk gestation), an association that persisted with multivariate analysis (P < 0.0001).
conclusionCrCP increased significantly from 23 to 31 wk gestation. The low CrCP observed in very premature infants may explain their ability to tolerate low ABP without global cerebral infarct or hemorrhage.
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Registered trials
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