Evidence map›Paper›PMID 25826116›Full record

ArticlePediatric research2015

Acute hypoglycemia results in reduced cortical neuronal injury in the developing IUGR rat.

Anne M Maliszewski-Hall, Ariel B Stein, Michelle Alexander, Kathleen Ennis, Raghavendra Rao

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anne M Maliszewski-HallDepartment of Pediatrics, Division of Neonatology, University of Minnesota, Minneapolis, MN, USA.
Ariel B SteinDepartment of Pediatrics, Division of Neonatology, University of Minnesota, Minneapolis, MN, USA.
Michelle AlexanderDepartment of Pediatrics, Division of Neonatology, University of Minnesota, Minneapolis, MN, USA.
Kathleen EnnisDepartment of Pediatrics, Division of Neonatology, University of Minnesota, Minneapolis, MN, USA.
Raghavendra RaoDepartment of Pediatrics, Division of Neonatology, University of Minnesota, Minneapolis, MN, USA.
University of Minnesota · US

Funding

Bedside to Bench and Back Again: Training Pediatricians in Translational ResearchK12HD068322 · NICHD · UNIVERSITY OF MINNESOTA · PI NEGLIA, JOSEPH P · 2011 to 2015
$1.9M
NICHD NIH HHS K12 HD068322NICHD NIH HHS L40 HD077666
6 · The paper itself

Abstract

backgroundHypoglycemia (HG) is common in intrauterine growth restricted (IUGR) neonates. In normally grown (NG) neonatal rats, acute HG causes neuronal injury in the brain; the cerebral cortex is more vulnerable than the hippocampus (HPC). We hypothesized that the IUGR brain is less vulnerable to HG-induced injury while preserving regional variation in vulnerability.

methodsWe induced IUGR via bilateral uterine artery ligation on gestational day 19 (term 22 d) rats. On postnatal day 14, insulin-induced HG of equivalent severity and duration (blood glucose < 40 mg/dl for 240 min) was produced in IUGR and NG (IUGR/HG and NG/HG). Neuronal injury in the cortex and HPC was quantified 6-72 h later using Fluoro-Jade B (FJB) histochemistry. The mRNA expression of monocarboxylate transporters, MCT1 and MCT2, and glucose transporters, GLUT1 and GLUT3, was determined using quantitative PCR.

resultsThere were fewer FJB-positive (FJB+) cells in the cortex of IUGR/HG; no difference was observed in FJB+ cells in HPC. Core body temperature was lower in IUGR/HG compared with NG/HG. MCT2 expression was increased in the IUGR cortex.

conclusionHG-induced neuronal injury is decreased in the cortex of the developing IUGR brain. Adaptations including systemic hypothermia and enhanced delivery of alternative substrates via MCT2 might protect against HG-induced neuronal injury in IUGR.

Indexed as

3-Hydroxybutyric AcidAnimalsBlood GlucoseBody TemperatureCerebral CortexDisease Models, AnimalFemaleFetal Growth RetardationGlucose Transporter Type 1Glucose Transporter Type 3HypoglycemiaMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersNeuronsRatsRats, Sprague-Dawley3-Hydroxybutyric AcidBlood GlucoseGlucose Transporter Type 1Glucose Transporter Type 3Monocarboxylate Transport Protein 1Monocarboxylic Acid TransportersSlc16a7 protein, ratSlc2a1 protein, ratSlc2a3 protein, ratSymporters

Identifiers

PMID25826116
PMCPMC4472557
OpenAlexW1967245113

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.