ArticleTranslational psychiatry2015
Stress inoculation modeled in mice.
Article in Translational psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 73 citations in OpenAlex.
- Transcriptome changes of disinhibited somatostatin neurons in the medial prefrontal cortex mediating male-specific stress resilience.Research square · 2026Article
- Neural Mechanisms of Social Homeostasis: Dynamic Range Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Synbiotic intervention reverses alcohol drinking-induced cognitive deficits in adolescent male mice by modulating the microbiota-gut-brain axis.Gut microbes · 2025Article
- Mild environmental stress inoculation promotes resilience to anxiety in female rats.Scientific reports · 2025Article
- Article
- Adaptation to Preceding Acute Psychological Stress is Associated With Subsequent Stress Coping Levels via Corticoid Receptors.Alpha psychiatry · 2025Article
- Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress exposure.Molecular psychiatry · 2025Article
- Self-experience of a negative event alters responses to others in similar states through prefrontal cortex CRF mechanisms.Nature neuroscience · 2025Article
- Translational models of stress and resilience: An applied neuroscience methodology review.Neuroscience applied · 2024Review
- Preclinical Models of Chronic Stress: Adaptation or Pathology?Biological psychiatry · 2023Review
- Potential resilience treatments for orangutans (Animal welfare (South Mimms, England) · 2023Article
- Epigenetic (re)programming of gene expression changes of CB1R and FAAH in the medial prefrontal cortex in response to early life and adolescence stress exposure.Frontiers in cellular neuroscience · 2023Article
- Resilience to depression: Implication for psychological vaccination.Frontiers in psychiatry · 2023Review
- Optimising Puppy Socialisation-Short- and Long-Term Effects of a Training Programme during the Early Socialisation Period.Animals : an open access journal from MDPI · 2022Article
- Towards Modeling Anhedonia and Its Treatment in Zebrafish.The international journal of neuropsychopharmacology · 2022Article
- Lateral hypothalamic galanin neurons are activated by stress and blunt anxiety-like behavior in mice.Behavioural brain research · 2022Article
- Responsiveness of domesticated goats towards various stressors following long-term cognitive test exposure.PeerJ · 2022Article
- Brief Maternal Separation Inoculates Against the Effects of Social Stress on Depression-Like Behavior and Cocaine Reward in Mice.Frontiers in pharmacology · 2022Article
- Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice.Nature communications · 2021Article
- Ethanol intake in male mice exposed to social defeat: Environmental enrichment potentiates resilience.Neurobiology of stress · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Stress inoculation entails intermittent exposure to mildly stressful situations that present opportunities to learn, practice and improve coping in the context of exposure psychotherapies and resiliency training. Here we investigate behavioral and hormonal aspects of stress inoculation modeled in mice. Mice randomized to stress inoculation or a control treatment condition were assessed for corticosterone stress hormone responses and behavior during open-field, object-exploration and tail-suspension tests. Stress inoculation training sessions that acutely increased plasma levels of corticosterone diminished subsequent immobility as a measure of behavioral despair on tail-suspension tests. Stress inoculation also decreased subsequent freezing in the open field despite comparable levels of thigmotaxis in mice from both treatment conditions. Stress inoculation subsequently decreased novel-object exploration latencies and reduced corticosterone responses to repeated restraint. These results demonstrate that stress inoculation acutely stimulates glucocorticoid signaling and then enhances subsequent indications of active coping behavior in mice. Unlike mouse models that screen for the absence of vulnerability to stress or presence of traits that occur in resilient individuals, stress inoculation training reflects an experience-dependent learning-like process that resembles interventions designed to build resilience in humans. Mouse models of stress inoculation may provide novel insights for new preventive strategies or therapeutic treatments of human psychiatric disorders that are triggered and exacerbated by stressful life events.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.