Evidence map›Paper›PMID 25826095›Full record

ArticleDNA and cell biology2015

A functional relay from progesterone to vitamin D in the immune system.

Chang H Kim

Open access · greenAbstract read
In one paragraph

Article in DNA and cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Chang H KimLaboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, College of Veterinary Medicine, Weldon School of Biomedical Engineering, Center for Cancer Research, Purdue University, West Lafayette, Indiana.
Purdue University West Lafayette · US

Funding

FoxP3+ T cells of mucosal tissuesR01AI074745 · NIAID · PURDUE UNIVERSITY · PI KIM, CHANG H · 2008 to 2012
$1.7M
Therapeutic delivery of FoxP3+ T cells to the intestineR01DK076616 · NIDDK · PURDUE UNIVERSITY · PI KIM, CHANG H · 2008 to 2012
$1.5M
Migration and function of Th17 cells in the gutR01AI080769 · NIAID · PURDUE UNIVERSITY · PI KIM, CHANG H · 2010 to 2013
$1.3M
A multiphoton confocal microscope for biomedical research at Purdue UniversityS10RR028293 · NCRR · PURDUE UNIVERSITY · PI KIM, CHANG H · 2010 to 2010
$893k
Determinants of BATF FunctionR21AI105620 · NIAID · PURDUE UNIVERSITY · PI TAPAROWSKY, ELIZABETH J · 2014 to 2015
$409k
NCRR NIH HHS 1S10RR028293NIAID NIH HHS 1R01AI080769NIAID NIH HHS R01 AI074745NIAID NIH HHS R01AI074745NIAID NIH HHS R01 AI080769NIAID NIH HHS R21AI105620NIDDK NIH HHS R01 DK076616NIDDK NIH HHS R01DK076616
6 · The paper itself

Abstract

Progesterone is a steroid hormone that promotes and maintains pregnancy. Vitamin D (vit. D), another steroid hormone, regulates calcium levels and bone health among many of its functions. The two hormones play important roles also in regulating the immune system. Recently, we discovered that the vitamin D receptor (VDR) is induced in T cells by progesterone. This finding connects the function of progesterone to that of vit. D and suggests that the two steroid hormones cooperate with each other for sequential and effective regulation of the immune system. Potential implications of the regulation in health and disease are discussed.

Indexed as

AnimalsCell CommunicationFemaleHumansImmune SystemPregnancyProgesteroneReceptors, CalcitriolVitamin DProgesteroneReceptors, CalcitriolVitamin D

Identifiers

PMID25826095
PMCPMC4484710
OpenAlexW1865657689

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.