ArticleGut1978
Vitamin D-3 intestinal absorption in vivo: influence of fatty acids, bile salts, and perfusate pH on absorption.
Article in Gut, 1978. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01268176 (Meal Effects on the 25OHD3 Response to Supplemental Vitamin D3), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Meal Effects on the 25OHD3 Response to Supplemental Vitamin D3
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials.Nutrients · 2021Pooled it
- Bioequivalence Studies of Vitamin D Gummies and Tablets in Healthy Adults: Results of a Cross-Over Study.Nutrients · 2019Trial
- Type of dietary fat is associated with the 25-hydroxyvitamin D3 increment in response to vitamin D supplementation.The Journal of clinical endocrinology and metabolism · 2011Trial
- Vitamin D: recent advances, associated factors, and its role in combating non-communicable diseases.NPJ science of food · 2025Review
- Dietary cholesterol increases body levels of oral administered vitamin DJournal of nutritional science · 2024Article
- The Possible Influence of Vitamin D Levels on the Development of Atrial Fibrillation-An Update.Nutrients · 2023Review
- Article
- Lactobacillus rhamnosus GG Promotes Intestinal Vitamin D Absorption by Upregulating Vitamin D Transporters in Senile Osteoporosis.Calcified tissue international · 2022Article
- Review
- The Action of Vitamin D in Adipose Tissue: Is There the Link between Vitamin D Deficiency and Adipose Tissue-Related Metabolic Disorders?International journal of molecular sciences · 2022Review
- The bridge of the gut-joint axis: Gut microbial metabolites in rheumatoid arthritis.Frontiers in immunology · 2022Review
- The Role of Vitamin D in Adipose Tissue Biology: Adipocyte Differentiation, Energy Metabolism, and Inflammation.Journal of lipid and atherosclerosis · 2021Review
- Implications of Vitamin D Research in Chickens can Advance Human Nutrition and Perspectives for the Future.Current developments in nutrition · 2021Article
- Post-surgery cholecystectomy, hepatectomy, and pancreatectomy patients increase the risk of osteoporotic vertebral fracture.Journal of bone and mineral metabolism · 2021Article
- Probiotics and Vitamin D/Vitamin D Receptor Pathway Interaction: Potential Therapeutic Implications in Inflammatory Bowel Disease.Frontiers in pharmacology · 2021Review
- Editorial: Vitamin D Deficiency and Sufficiency in Reproduction and Bone Metabolism.Frontiers in endocrinology · 2021Article
- Co-administration of vitamin D3 andAnnals of microbiology · 2021Article
- Effects of high fat diet-induced obesity on vitamin D metabolism and tissue distribution in vitamin D deficient or supplemented mice.Nutrition & metabolism · 2020Article
- Is calcifediol better than cholecalciferol for vitamin D supplementation?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Review
- Lithocholic Acid Is a Vitamin D Receptor Ligand That Acts Preferentially in the Ileum.International journal of molecular sciences · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal absorption of vitamin D-3 in physiological concentrations was studied in the live unanesthetised rat. In both the jejunum and the ileum a linear relationship was found between the absorption rate of the vitamin and its intraluminal concentration. Increasing the sodium taurocholate concentation in the perfusate above 5mM did not change ileal absorption rate but did decrease jejunal absorption rate. The vitamin's rate of absorption was raised by increases in either the hydrogen ion concentration in vivo is mediated by passive diffusion. The rate of absorption of ttion or the perfusate's flow rate. Addition of 2.5 mM fatty acids of varying chain length and degrees of saturation resulted in a decrease in the rate of vitamin D-3 absorption. These experiments indicate that vitamin D-3 absorption in vivo is mediated by passive diffusion. The rate of absorption of the vitamin is influenced by the composition of the perfusate and the thickness of the unstirred layer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.