Evidence map›Paper›PMID 25825948›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2015

Sex Differences in the Effects of Weight Loss Diets on Bone Mineral Density and Body Composition: POUNDS LOST Trial.

Amir Tirosh, Russell J de Souza, Frank Sacks, George A Bray, Steven R Smith, Meryl S LeBoff

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. The effects of weight loss approaches on bone mineral density in adults: a systematic review and meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amir TiroshDivision of Endocrinology, Diabetes, and Hypertension (A.T., M.S.L.), Brigham and Women's Hospital, Boston, Massachusetts 02115; Harvard Medical School (A.T., M.S.L., F.S.), Boston, Massachusetts 02115; Department of Clinical Epidemiology and Biostatistics (R.J.d.S.), McMaster University, Hamilton, Ontario, L8S 4L8 Canada; Channing Laboratory (F.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Nutrition (F.S.), Harvard School of Public Health, Boston, Massachusetts 02115; and Pennington Biomedical Research Center of the Louisiana State University System (G.A.B., S.R.S.), Baton Rouge, Louisiana 70808.
Russell J de SouzaDivision of Endocrinology, Diabetes, and Hypertension (A.T., M.S.L.), Brigham and Women's Hospital, Boston, Massachusetts 02115; Harvard Medical School (A.T., M.S.L., F.S.), Boston, Massachusetts 02115; Department of Clinical Epidemiology and Biostatistics (R.J.d.S.), McMaster University, Hamilton, Ontario, L8S 4L8 Canada; Channing Laboratory (F.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Nutrition (F.S.), Harvard School of Public Health, Boston, Massachusetts 02115; and Pennington Biomedical Research Center of the Louisiana State University System (G.A.B., S.R.S.), Baton Rouge, Louisiana 70808.
Frank SacksDivision of Endocrinology, Diabetes, and Hypertension (A.T., M.S.L.), Brigham and Women's Hospital, Boston, Massachusetts 02115; Harvard Medical School (A.T., M.S.L., F.S.), Boston, Massachusetts 02115; Department of Clinical Epidemiology and Biostatistics (R.J.d.S.), McMaster University, Hamilton, Ontario, L8S 4L8 Canada; Channing Laboratory (F.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Nutrition (F.S.), Harvard School of Public Health, Boston, Massachusetts 02115; and Pennington Biomedical Research Center of the Louisiana State University System (G.A.B., S.R.S.), Baton Rouge, Louisiana 70808.
George A BrayDivision of Endocrinology, Diabetes, and Hypertension (A.T., M.S.L.), Brigham and Women's Hospital, Boston, Massachusetts 02115; Harvard Medical School (A.T., M.S.L., F.S.), Boston, Massachusetts 02115; Department of Clinical Epidemiology and Biostatistics (R.J.d.S.), McMaster University, Hamilton, Ontario, L8S 4L8 Canada; Channing Laboratory (F.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Nutrition (F.S.), Harvard School of Public Health, Boston, Massachusetts 02115; and Pennington Biomedical Research Center of the Louisiana State University System (G.A.B., S.R.S.), Baton Rouge, Louisiana 70808.
Steven R SmithDivision of Endocrinology, Diabetes, and Hypertension (A.T., M.S.L.), Brigham and Women's Hospital, Boston, Massachusetts 02115; Harvard Medical School (A.T., M.S.L., F.S.), Boston, Massachusetts 02115; Department of Clinical Epidemiology and Biostatistics (R.J.d.S.), McMaster University, Hamilton, Ontario, L8S 4L8 Canada; Channing Laboratory (F.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Nutrition (F.S.), Harvard School of Public Health, Boston, Massachusetts 02115; and Pennington Biomedical Research Center of the Louisiana State University System (G.A.B., S.R.S.), Baton Rouge, Louisiana 70808.
Meryl S LeBoffDivision of Endocrinology, Diabetes, and Hypertension (A.T., M.S.L.), Brigham and Women's Hospital, Boston, Massachusetts 02115; Harvard Medical School (A.T., M.S.L., F.S.), Boston, Massachusetts 02115; Department of Clinical Epidemiology and Biostatistics (R.J.d.S.), McMaster University, Hamilton, Ontario, L8S 4L8 Canada; Channing Laboratory (F.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Nutrition (F.S.), Harvard School of Public Health, Boston, Massachusetts 02115; and Pennington Biomedical Research Center of the Louisiana State University System (G.A.B., S.R.S.), Baton Rouge, Louisiana 70808.

Funding

Zoledronic Acid in Treatment of Osteoporosis in PostmenoM01RR002635 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI WILLIAMS, GORDON H · 1985 to 2008
$48.4M
Dietary Macronutrients and Weight LossU01HL073286 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SACKS, FRANK M · 2003 to 2008
$7.6M
VITamin D and OmegA-3 TriaL (VITAL): Interrelationship of Vitamin D and Vitamin K on BoneR01AR059775 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LEBOFF, MERYL SUSAN · 2012 to 2022
$3.9M
NCRR NIH HHS M01 RR002635NCRR NIH HHS RR-02635NHLBI NIH HHS HL073286NHLBI NIH HHS U01 HL073286NIAMS NIH HHS R01 AR059775
6 · The paper itself

Abstract

contextWeight loss is associated with reduction in bone mineral density (BMD).

objectiveThe objective was to address the role of changes in fat mass (FM) and lean mass (LM) in BMD decline in both sexes.

designA 2-year randomized controlled trial, the Preventing Overweight Using Novel Dietary Strategies (POUNDS-LOST).

settingThe setting was the general community. PATIENTS OR OTHER

participantsEnrolled were 424 overweight and obese participants (mean age, 52 ± 9 y; 57% females).

interventionIntervention included weight loss diets differing in fat, protein, and carbohydrates.

main outcome measuresMain outcome measures were change in spine, total hip (TH), and femoral neck (FN) BMD and sex differences after dietary intervention.

resultsAt baseline, a stronger correlation between BMD and body composition measurements was observed in women, primarily with LM (r = 0.419, 0.507, and 0.523 for spine, FN, and TH, respectively; all P < .001). In men, only LM correlated with hip BMD (r = 0.298; P < .001). Mean weight loss at 2 years was -6.9%, without differences among diets. Two-year changes in BMD were 0.005 (P = .04), -0.014 (P < .001), and -0.014 g/cm(2) (P < .001), at the spine, TH, and FN, respectively. These changes directly correlated with changes in LM in women (r = 0.200, 0.324, and 0.260 for spine, FN, and TH, respectively), whereas FM loss correlated only with changes in TH BMD (0.274; P < .001). In men, changes in LM (-0.323; P < .001) and FM (-0.213; P = .027) negatively correlated with changes in spine BMD.

conclusionsWeight loss diets result in sex-specific effects on BMD. Although men exhibited a paradoxical increase in spine BMD, women tended to decrease in BMD at all sites.

Indexed as

Body CompositionBone DensityDiet, ReducingWeight LossAdultAgedBody Mass IndexFemaleHumansMaleMiddle AgedObesityOverweightSex Characteristics

Identifiers

PMID25825948
PMCPMC4454797

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.