Trial reportThe Journal of clinical endocrinology and metabolism2015
Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat.
2 registry-linked trialsOpen access · greenAbstract readClinical Trial
In one paragraph
Trial report in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 118 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 4 pooled it
17.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adverse Metabolic Effects of Dietary Sugar: Ad Libitum vs Energy-balanced Diets
Genetic-specific Effects of Fructose on Liver Lipogenesis
Who cites it
118 citing papers in PubMed, 4 syntheses or guidelines pooled it, 225 citations in OpenAlex.
- The Impact of Sugar Source on the Relationships Between Free Sugars Intake and Health: A Secondary Analysis.Nutrients · 2026Pooled it
- Pooled it
- Effects of dietary macronutrients on liver fat content in adults: a systematic review and meta-analysis of randomized controlled trials.European journal of clinical nutrition · 2021Pooled it
- Food sources of fructose-containing sugars and glycaemic control: systematic review and meta-analysis of controlled intervention studies.BMJ (Clinical research ed.) · 2018Pooled it
- Dietary sugar restriction reduces hepatic de novo lipogenesis in adolescent boys with fatty liver disease.The Journal of clinical investigation · 2021Trial
- Trial
- Consuming glucose-sweetened, not fructose-sweetened, beverages increases fasting insulin in healthy humans.European journal of clinical nutrition · 2019Trial
- Impact of liver fat on the differential partitioning of hepatic triacylglycerol into VLDL subclasses on high and low sugar diets.Clinical science (London, England : 1979) · 2017Trial
- Trial
- No differential effect of beverages sweetened with fructose, high-fructose corn syrup, or glucose on systemic or adipose tissue inflammation in normal-weight to obese adults: a randomized controlled trial.The American journal of clinical nutrition · 2016Trial
- Sugar Shockwaves: How the Fructose-Glucose-ChREBP Pathway Hijacks Liver Metabolism.Life (Basel, Switzerland) · 2026Review
- Hyperinsulinaemia as a cause of obesity and cardiometabolic diseases.Nature reviews. Endocrinology · 2026Review
- Fructose: metabolic signal and modern hazard.Nature metabolism · 2026Review
- Myths and facts about the role of diet in metabolic dysfunction-associated steatotic liver disease.World journal of hepatology · 2025Review
- Article
- Fructose metabolism and its roles in metabolic diseases, inflammatory diseases, and cancer.Molecular biomedicine · 2025Review
- Nutrient-Induced Changes of Liver Fat Content in Humans.Physiological research · 2025Review
- The Impact of Dietary Sugars and Saturated Fats on Body and Liver Fat in a Healthcare Worker Population.Nutrients · 2025Article
- De novo lipid synthesis in cardiovascular tissue and disease.Atherosclerosis · 2025Review
- Prebiotic food intake and biochemical measures in diabetic patients: A cross-sectional study from the Sabzevar Persian Cohort.PloS one · 2025Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Jean-Marc SchwarzTouro University (J.M.S., A.D., J.L.P., N.B.), Vallejo, California 94594; Department of Medicine (J.M.S., M.E.W., T.P.B., M.N.R., M.S., K.M.), University of California, San Francisco, San Francisco, California 94143; Division of Endocrinology (J.M.S., M.J.W., M.E.W., V.W.T., M.N.R., M.S., K.M.), San Francisco General Hospital, San Francisco, California 94110; Department of Radiology and Biomedical Imaging (S.M.N.), University of California, San Francisco, San Francisco, California 94143; UCSF Clinical and Translational Science Institute Clinical Research Center (L.A.H., V.W.T.), San Francisco, California 94143; and The Gladstone Institute of Cardiovascular Disease (T.P.B.), San Francisco, California 94158.
Susan M NoworolskiTouro University (J.M.S., A.D., J.L.P., N.B.), Vallejo, California 94594; Department of Medicine (J.M.S., M.E.W., T.P.B., M.N.R., M.S., K.M.), University of California, San Francisco, San Francisco, California 94143; Division of Endocrinology (J.M.S., M.J.W., M.E.W., V.W.T., M.N.R., M.S., K.M.), San Francisco General Hospital, San Francisco, California 94110; Department of Radiology and Biomedical Imaging (S.M.N.), University of California, San Francisco, San Francisco, California 94143; UCSF Clinical and Translational Science Institute Clinical Research Center (L.A.H., V.W.T.), San Francisco, California 94143; and The Gladstone Institute of Cardiovascular Disease (T.P.B.), San Francisco, California 94158.
Michael J WenTouro University (J.M.S., A.D., J.L.P., N.B.), Vallejo, California 94594; Department of Medicine (J.M.S., M.E.W., T.P.B., M.N.R., M.S., K.M.), University of California, San Francisco, San Francisco, California 94143; Division of Endocrinology (J.M.S., M.J.W., M.E.W., V.W.T., M.N.R., M.S., K.M.), San Francisco General Hospital, San Francisco, California 94110; Department of Radiology and Biomedical Imaging (S.M.N.), University of California, San Francisco, San Francisco, California 94143; UCSF Clinical and Translational Science Institute Clinical Research Center (L.A.H., V.W.T.), San Francisco, California 94143; and The Gladstone Institute of Cardiovascular Disease (T.P.B.), San Francisco, California 94158.
Artem DyachenkoTouro University (J.M.S., A.D., J.L.P., N.B.), Vallejo, California 94594; Department of Medicine (J.M.S., M.E.W., T.P.B., M.N.R., M.S., K.M.), University of California, San Francisco, San Francisco, California 94143; Division of Endocrinology (J.M.S., M.J.W., M.E.W., V.W.T., M.N.R., M.S., K.M.), San Francisco General Hospital, San Francisco, California 94110; Department of Radiology and Biomedical Imaging (S.M.N.), University of California, San Francisco, San Francisco, California 94143; UCSF Clinical and Translational Science Institute Clinical Research Center (L.A.H., V.W.T.), San Francisco, California 94143; and The Gladstone Institute of Cardiovascular Disease (T.P.B.), San Francisco, California 94158.
Jessica L PriorTouro University (J.M.S., A.D., J.L.P., N.B.), Vallejo, California 94594; Department of Medicine (J.M.S., M.E.W., T.P.B., M.N.R., M.S., K.M.), University of California, San Francisco, San Francisco, California 94143; Division of Endocrinology (J.M.S., M.J.W., M.E.W., V.W.T., M.N.R., M.S., K.M.), San Francisco General Hospital, San Francisco, California 94110; Department of Radiology and Biomedical Imaging (S.M.N.), University of California, San Francisco, San Francisco, California 94143; UCSF Clinical and Translational Science Institute Clinical Research Center (L.A.H., V.W.T.), San Francisco, California 94143; and The Gladstone Institute of Cardiovascular Disease (T.P.B.), San Francisco, California 94158.
Melissa E WeinbergTouro University (J.M.S., A.D., J.L.P., N.B.), Vallejo, California 94594; Department of Medicine (J.M.S., M.E.W., T.P.B., M.N.R., M.S., K.M.), University of California, San Francisco, San Francisco, California 94143; Division of Endocrinology (J.M.S., M.J.W., M.E.W., V.W.T., M.N.R., M.S., K.M.), San Francisco General Hospital, San Francisco, California 94110; Department of Radiology and Biomedical Imaging (S.M.N.), University of California, San Francisco, San Francisco, California 94143; UCSF Clinical and Translational Science Institute Clinical Research Center (L.A.H., V.W.T.), San Francisco, California 94143; and The Gladstone Institute of Cardiovascular Disease (T.P.B.), San Francisco, California 94158.
Laurie A HerraizTouro University (J.M.S., A.D., J.L.P., N.B.), Vallejo, California 94594; Department of Medicine (J.M.S., M.E.W., T.P.B., M.N.R., M.S., K.M.), University of California, San Francisco, San Francisco, California 94143; Division of Endocrinology (J.M.S., M.J.W., M.E.W., V.W.T., M.N.R., M.S., K.M.), San Francisco General Hospital, San Francisco, California 94110; Department of Radiology and Biomedical Imaging (S.M.N.), University of California, San Francisco, San Francisco, California 94143; UCSF Clinical and Translational Science Institute Clinical Research Center (L.A.H., V.W.T.), San Francisco, California 94143; and The Gladstone Institute of Cardiovascular Disease (T.P.B.), San Francisco, California 94158.
Viva W TaiTouro University (J.M.S., A.D., J.L.P., N.B.), Vallejo, California 94594; Department of Medicine (J.M.S., M.E.W., T.P.B., M.N.R., M.S., K.M.), University of California, San Francisco, San Francisco, California 94143; Division of Endocrinology (J.M.S., M.J.W., M.E.W., V.W.T., M.N.R., M.S., K.M.), San Francisco General Hospital, San Francisco, California 94110; Department of Radiology and Biomedical Imaging (S.M.N.), University of California, San Francisco, San Francisco, California 94143; UCSF Clinical and Translational Science Institute Clinical Research Center (L.A.H., V.W.T.), San Francisco, California 94143; and The Gladstone Institute of Cardiovascular Disease (T.P.B.), San Francisco, California 94158.
Nathalie BergeronTouro University (J.M.S., A.D., J.L.P., N.B.), Vallejo, California 94594; Department of Medicine (J.M.S., M.E.W., T.P.B., M.N.R., M.S., K.M.), University of California, San Francisco, San Francisco, California 94143; Division of Endocrinology (J.M.S., M.J.W., M.E.W., V.W.T., M.N.R., M.S., K.M.), San Francisco General Hospital, San Francisco, California 94110; Department of Radiology and Biomedical Imaging (S.M.N.), University of California, San Francisco, San Francisco, California 94143; UCSF Clinical and Translational Science Institute Clinical Research Center (L.A.H., V.W.T.), San Francisco, California 94143; and The Gladstone Institute of Cardiovascular Disease (T.P.B.), San Francisco, California 94158.
Thomas P BersotTouro University (J.M.S., A.D., J.L.P., N.B.), Vallejo, California 94594; Department of Medicine (J.M.S., M.E.W., T.P.B., M.N.R., M.S., K.M.), University of California, San Francisco, San Francisco, California 94143; Division of Endocrinology (J.M.S., M.J.W., M.E.W., V.W.T., M.N.R., M.S., K.M.), San Francisco General Hospital, San Francisco, California 94110; Department of Radiology and Biomedical Imaging (S.M.N.), University of California, San Francisco, San Francisco, California 94143; UCSF Clinical and Translational Science Institute Clinical Research Center (L.A.H., V.W.T.), San Francisco, California 94143; and The Gladstone Institute of Cardiovascular Disease (T.P.B.), San Francisco, California 94158.
Madhu N RaoTouro University (J.M.S., A.D., J.L.P., N.B.), Vallejo, California 94594; Department of Medicine (J.M.S., M.E.W., T.P.B., M.N.R., M.S., K.M.), University of California, San Francisco, San Francisco, California 94143; Division of Endocrinology (J.M.S., M.J.W., M.E.W., V.W.T., M.N.R., M.S., K.M.), San Francisco General Hospital, San Francisco, California 94110; Department of Radiology and Biomedical Imaging (S.M.N.), University of California, San Francisco, San Francisco, California 94143; UCSF Clinical and Translational Science Institute Clinical Research Center (L.A.H., V.W.T.), San Francisco, California 94143; and The Gladstone Institute of Cardiovascular Disease (T.P.B.), San Francisco, California 94158.
Morris SchambelanTouro University (J.M.S., A.D., J.L.P., N.B.), Vallejo, California 94594; Department of Medicine (J.M.S., M.E.W., T.P.B., M.N.R., M.S., K.M.), University of California, San Francisco, San Francisco, California 94143; Division of Endocrinology (J.M.S., M.J.W., M.E.W., V.W.T., M.N.R., M.S., K.M.), San Francisco General Hospital, San Francisco, California 94110; Department of Radiology and Biomedical Imaging (S.M.N.), University of California, San Francisco, San Francisco, California 94143; UCSF Clinical and Translational Science Institute Clinical Research Center (L.A.H., V.W.T.), San Francisco, California 94143; and The Gladstone Institute of Cardiovascular Disease (T.P.B.), San Francisco, California 94158.
Kathleen MulliganTouro University (J.M.S., A.D., J.L.P., N.B.), Vallejo, California 94594; Department of Medicine (J.M.S., M.E.W., T.P.B., M.N.R., M.S., K.M.), University of California, San Francisco, San Francisco, California 94143; Division of Endocrinology (J.M.S., M.J.W., M.E.W., V.W.T., M.N.R., M.S., K.M.), San Francisco General Hospital, San Francisco, California 94110; Department of Radiology and Biomedical Imaging (S.M.N.), University of California, San Francisco, San Francisco, California 94143; UCSF Clinical and Translational Science Institute Clinical Research Center (L.A.H., V.W.T.), San Francisco, California 94143; and The Gladstone Institute of Cardiovascular Disease (T.P.B.), San Francisco, California 94158.
University of California, San Francisco · USSan Francisco General Hospital · USTouro University California · USGladstone Institutes · US
Funding
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0MResearch BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8MDe novo lipogenesis in the pathogenesis of non-alcoholic fatty liver diseaseR01DK078133 · NIDDK · TOURO UNIVERSITY OF CALIFORNIA · PI SCHWARZ, JEAN-MARC · 2007 to 2010
$1.3MNCATS NIH HHS UL 1 TR000004NIDDK NIH HHS DK078133NIDDK NIH HHS P30 DK063720NIDDK NIH HHS R01 DK078133
Abstract
contextConsumption of high-fructose diets promotes hepatic fatty acid synthesis (de novo lipogenesis [DNL]) and an atherogenic lipid profile. It is unclear whether these effects occur independent of positive energy balance and weight gain.
objectivesWe compared the effects of a high-fructose, (25% of energy content) weight-maintaining diet to those of an isocaloric diet with the same macronutrient distribution but in which complex carbohydrate (CCHO) was substituted for fructose. DESIGN, SETTING, AND
participantsEight healthy men were studied as inpatients for consecutive 9-day periods. Stable isotope tracers were used to measure fractional hepatic DNL and endogenous glucose production (EGP) and its suppression during a euglycemic-hyperinsulinemic clamp. Liver fat was measured by magnetic resonance spectroscopy.
resultsWeight remained stable. Regardless of the order in which the diets were fed, the high-fructose diet was associated with both higher DNL (average, 18.6 ± 1.4% vs 11.0 ± 1.4% for CCHO; P = .001) and higher liver fat (median, +137% of CCHO; P = .016) in all participants. Fasting EGP and insulin-mediated glucose disposal did not differ significantly, but EGP during hyperinsulinemia was greater (0.60 ± 0.07 vs 0.46 ± 0.06 mg/kg/min; P = .013) with the high-fructose diet, suggesting blunted suppression of EGP.
conclusionShort-term high-fructose intake was associated with increased DNL and liver fat in healthy men fed weight-maintaining diets.
Indexed as
Adipose TissueAdiposityAdolescentAdultAgedBody WeightDietary CarbohydratesFructoseGlucoseHumansLipid MetabolismLipogenesisLiverMaleMiddle AgedYoung AdultDietary CarbohydratesFructoseGlucose
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT02548767ClinicalTrials.gov
NCT03783195ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.