ArticleProceedings of the National Academy of Sciences of the United States of America2015
Candidate ionotropic taste receptors in the Drosophila larva.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed, 99 citations in OpenAlex.
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- Heterologous investigation of metabotropic and ionotropic odorant receptors in ab3A neurons ofFrontiers in molecular biosciences · 2023Article
- The chemosensory system of theFly · 2022Review
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- Ionotropic receptors in the turnip moth Agrotis segetum respond to repellent medium-chain fatty acids.BMC biology · 2022Article
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- Taste sensing and sugar detection mechanisms ineLife · 2021Article
- The genome of the stable fly, Stomoxys calcitrans, reveals potential mechanisms underlying reproduction, host interactions, and novel targets for pest control.BMC biology · 2021Article
- Genome-enabled insights into the biology of thrips as crop pests.BMC biology · 2020Article
- Single cell transcriptomes reveal expression patterns of chemoreceptor genes in olfactory sensory neurons of the Caribbean spiny lobster, Panulirus argus.BMC genomics · 2020Article
- Developmental and sexual divergence in the olfactory system of the marine insect Clunio marinus.Scientific reports · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
We examine in Drosophila a group of ∼35 ionotropic receptors (IRs), the IR20a clade, about which remarkably little is known. Of 28 genes analyzed, GAL4 drivers representing 11 showed expression in the larva. Eight drivers labeled neurons of the pharynx, a taste organ, and three labeled neurons of the body wall that may be chemosensory. Expression was not observed in neurons of one taste organ, the terminal organ, although these neurons express many drivers of the Gr (Gustatory receptor) family. For most drivers of the IR20a clade, we observed expression in a single pair of cells in the animal, with limited coexpression, and only a fraction of pharyngeal neurons are labeled. The organization of IR20a clade expression thus appears different from the organization of the Gr family or the Odor receptor (Or) family in the larva. A remarkable feature of the larval pharynx is that some of its organs are incorporated into the adult pharynx, and several drivers of this clade are expressed in the pharynx of both larvae and adults. Different IR drivers show different developmental dynamics across the larval stages, either increasing or decreasing. Among neurons expressing drivers in the pharynx, two projection patterns can be distinguished in the CNS. Neurons exhibiting these two kinds of projection patterns may activate different circuits, possibly signaling the presence of cues with different valence. Taken together, the simplest interpretation of our results is that the IR20a clade encodes a class of larval taste receptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.