ArticleProceedings of the National Academy of Sciences of the United States of America2015
Metabolic connectivity as a driver of host and endosymbiont integration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- The mosaic of aquatic photorespiration: evolution, diversity, and global biogeochemical impacts.The New phytologist · 2026Review
- Glycogen deficiency impairs diurnal energy metabolism and cell division in Synechocystis.Plant physiology · 2026Article
- Dating the Origin and Spread of Plastids and Chromatophores.International journal of molecular sciences · 2025Article
- Evidence of a putative COEnvironmental microbiology reports · 2024Article
- TheeLife · 2024Article
- Taming the perils of photosynthesis by eukaryotes: constraints on endosymbiotic evolution in aquatic ecosystems.Communications biology · 2023Review
- Co-option of a conserved host glutamine transporter facilitates aphid/Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Tailoring confocal microscopy for real-time analysis of photosynthesis at single-cell resolution.Cell reports methods · 2023Article
- mTORC1 regulates phagosome digestion of symbiotic bacteria for intracellular nutritional symbiosis in a deep-sea mussel.Science advances · 2023Article
- Impact of direct physical association and motility on fitness of a synthetic interkingdom microbial community.The ISME journal · 2023Article
- Why is primary endosymbiosis so rare?The New phytologist · 2021Review
- Cytoklepty in the plankton: A host strategy to optimize the bioenergetic machinery of endosymbiotic algae.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Puzzle of Metabolite Exchange and Identification of Putative Octotrico Peptide Repeat Expression Regulators in the Nascent Photosynthetic Organelles ofFrontiers in microbiology · 2020Article
- Horizontal and endosymbiotic gene transfer in early plastid evolution.The New phytologist · 2019Review
- Ion and metabolite transport in the chloroplast of algae: lessons from land plants.Cellular and molecular life sciences : CMLS · 2018Review
- Genome Analysis of Endomicrobium proavitum Suggests Loss and Gain of Relevant Functions during the Evolution of Intracellular Symbionts.Applied and environmental microbiology · 2017Article
- Natural selection drove metabolic specialization of the chromatophore in Paulinella chromatophora.BMC evolutionary biology · 2017Article
- Localization and Evolution of Putative Triose Phosphate Translocators in the Diatom Phaeodactylum tricornutum.Genome biology and evolution · 2015Article
- Symbiosis becoming permanent: Survival of the luckiest.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The origin of oxygenic photosynthesis in the Archaeplastida common ancestor was foundational for the evolution of multicellular life. It is very likely that the primary endosymbiosis that explains plastid origin relied initially on the establishment of a metabolic connection between the host cell and captured cyanobacterium. We posit that these connections were derived primarily from existing host-derived components. To test this idea, we used phylogenomic and network analysis to infer the phylogenetic origin and evolutionary history of 37 validated plastid innermost membrane (permeome) metabolite transporters from the model plant Arabidopsis thaliana. Our results show that 57% of these transporter genes are of eukaryotic origin and that the captured cyanobacterium made a relatively minor (albeit important) contribution to the process. We also tested the hypothesis that the bacterium-derived hexose-phosphate transporter UhpC might have been the primordial sugar transporter in the Archaeplastida ancestor. Bioinformatic and protein localization studies demonstrate that this protein in the extremophilic red algae Galdieria sulphuraria and Cyanidioschyzon merolae are plastid targeted. Given this protein is also localized in plastids in the glaucophyte alga Cyanophora paradoxa, we suggest it played a crucial role in early plastid endosymbiosis by connecting the endosymbiont and host carbon storage networks. In summary, our work significantly advances understanding of plastid integration and favors a host-centric view of endosymbiosis. Under this view, nuclear genes of either eukaryotic or bacterial (noncyanobacterial) origin provided key elements of the toolkit needed for establishing metabolic connections in the primordial Archaeplastida lineage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.