ArticleProceedings of the National Academy of Sciences of the United States of America2015
Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
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Who cites it
95 citing papers in PubMed, 168 citations in OpenAlex.
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- RADIP technology comprehensively identifies H3K27me3-associated RNA-chromatin interactions.Nucleic acids research · 2024Article
- Replication-coupled inheritance of chromatin states.Cell insight · 2024Review
- A feedback loop between plakophilin 4 and YAP signaling regulates keratinocyte differentiation.iScience · 2024Article
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- Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency.Molecular cell · 2024Article
- The impact of DNA methylation on CTCF-mediated 3D genome organization.Nature structural & molecular biology · 2024Review
- Broad H3K4me3 Domain Is Associated with Spatial Coherence during Mammalian Embryonic Development.bioRxiv : the preprint server for biology · 2023Article
- Dispersal of PRC1 condensates disrupts polycomb chromatin domains and loops.Life science alliance · 2023Article
35 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Embryogenesis requires the precise activation and repression of many transcriptional regulators. The Polycomb group proteins and the associated H3K27me3 histone mark are essential to maintain the inactive state of many of these genes. Mammalian Hox genes are targets of Polycomb proteins and form local 3D clusters centered on the H3K27me3 mark. More distal contacts have also been described, yet their selectivity, dynamics, and relation to other layers of chromatin organization remained elusive. We report that repressed Hox genes form mutual intra- and interchromosomal interactions with other genes located in strong domains labeled by H3K27me3. These interactions occur in a central and active nuclear environment that consists of the HiC compartment A, away from peripheral lamina-associated domains. Interactions are independent of nearby H3K27me3-marked loci and determined by chromosomal distance and cell-type-specific scaling factors, thus inducing a moderate reorganization during embryogenesis. These results provide a simplified view of nuclear organization whereby Polycomb proteins may have evolved to repress genes located in gene-dense regions whose position is restricted to central, active, nuclear environments.
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