ArticleProceedings of the National Academy of Sciences of the United States of America2015
Tectal microcircuit generating visual selection commands on gaze-controlling neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Central coordination of electromotor and locomotor pathways in the weakly electric fish Brevimyrus niger.Research square · 2026Article
- Brain-wide arousal signals are segregated from movement planning in the superior colliculus of the macaque.eLife · 2026Article
- Recurrent circuits encode de novo visual center-surround computations in the mouse superior colliculus.PLoS biology · 2025Article
- Direct retino-iridal projections and intrinsic iris contraction mediate the pupillary light reflex in early vertebrates.Communications biology · 2024Article
- Pathways from the Superior Colliculus to the Basal Ganglia.Current neuropharmacology · 2024Review
- Unravelling the functional development of vertebrate pathways controlling gaze.Frontiers in cell and developmental biology · 2023Article
- From retina to motoneurons: A substrate for visuomotor transformation in salamanders.The Journal of comparative neurology · 2022Article
- Conserved subcortical processing in visuo-vestibular gaze control.Nature communications · 2022Article
- Dopamine modulates visual threat processing in the superior colliculus via D2 receptors.iScience · 2022Article
- Neuroscience needs evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Evolution of behavioural control from chordates to primates.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- The neural bases of vertebrate motor behaviour through the lens of evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- The Ecological View of Selective Attention.Frontiers in integrative neuroscience · 2022Article
- The Dopaminergic Control of Movement-Evolutionary Considerations.International journal of molecular sciences · 2021Review
- The tectum/superior colliculus as the vertebrate solution for spatial sensory integration and action.Current biology : CB · 2021Review
- Unraveling circuits of visual perception and cognition through the superior colliculus.Neuron · 2021Review
- The evolutionary origin of visual and somatosensory representation in the vertebrate pallium.Nature ecology & evolution · 2020Article
- GABAergic cell types in the superficial layers of the mouse superior colliculus.The Journal of comparative neurology · 2020Article
- Resynthesizing behavior through phylogenetic refinement.Attention, perception & psychophysics · 2019Article
- No one knows what attention is.Attention, perception & psychophysics · 2019Review
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The optic tectum (called superior colliculus in mammals) is critical for eye-head gaze shifts as we navigate in the terrain and need to adapt our movements to the visual scene. The neuronal mechanisms underlying the tectal contribution to stimulus selection and gaze reorientation remains, however, unclear at the microcircuit level. To analyze this complex--yet phylogenetically conserved--sensorimotor system, we developed a novel in vitro preparation in the lamprey that maintains the eye and midbrain intact and allows for whole-cell recordings from prelabeled tectal gaze-controlling cells in the deep layer, while visual stimuli are delivered. We found that receptive field activation of these cells provide monosynaptic retinal excitation followed by local GABAergic inhibition (feedforward). The entire remaining retina, on the other hand, elicits only inhibition (surround inhibition). If two stimuli are delivered simultaneously, one inside and one outside the receptive field, the former excitatory response is suppressed. When local inhibition is pharmacologically blocked, the suppression induced by competing stimuli is canceled. We suggest that this rivalry between visual areas across the tectal map is triggered through long-range inhibitory tectal connections. Selection commands conveyed via gaze-controlling neurons in the optic tectum are, thus, formed through synaptic integration of local retinotopic excitation and global tectal inhibition. We anticipate that this mechanism not only exists in lamprey but is also conserved throughout vertebrate evolution.
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