Trial reportProceedings of the National Academy of Sciences of the United States of America2015
Lag threads organize the brain's intrinsic activity.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 116 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
116 citing papers in PubMed.
- Retinotopic coding organizes the interaction between internally and externally oriented brain networks.eLife · 2026Article
- Lag-adjusted functional network connectivity reveals sensorimotor and higher cognitive network alterations in depression.Research square · 2026Article
- Three parsimonious spatiotemporal patterns in cerebellum reveal individual traits in function and behavior.Nature communications · 2026Article
- Parallel processing chains span cytoarchitectures to organize association cortex.bioRxiv : the preprint server for biology · 2026Article
- Time-resolved directional organization of brain networks: distinct strength and temporal signatures from neurophysiology to disease.bioRxiv : the preprint server for biology · 2026Article
- Channel Capacity for Time-Resolved Effective Connectivity in Functional Neuroimaging.bioRxiv : the preprint server for biology · 2026Article
- Time-Varying Directed Interactions in Functional Brain Networks: Modeling and Validation.ArXiv · 2026Article
- Sensory encoding and memory retrieval are coordinated with propagating waves in the human brain.Nature communications · 2026Article
- Cross-population amplitude coupling in high-dimensional oscillatory neural time series.Frontiers in computational neuroscience · 2026Article
- Dynamic Interactions Between Hemispheres Reveal a Compensatory Pathway for Motor Recovery in Moderate-to-Severe Subcortical Stroke.Journal of stroke · 2026Article
- Spatiotemporal Characterization of the Functional MRI Latency Structure with Respect to Neural Signaling and Brain Hierarchy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Emergence of a temporal processing gradient from naturalistic inputs and network connectivity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Review
- Sensory Encoding Alternates With Hippocampal Ripples across Cycles of Forebrain Spiking Cascades.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Comparison of derivative-based and correlation-based methods to estimate effective connectivity in neural networks.Scientific reports · 2025Article
- Time-Varying Spatial Propagation of Brain Networks in fMRI Data.Human brain mapping · 2025Article
- Sleep-stage dependent patterning of slowly propagating brain activity.Npj biological timing and sleep · 2025Article
- Prenatal social disadvantage is associated with alterations in functional networks at birth.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain.Cell reports · 2024Article
- The Hopf whole-brain model and its linear approximation.Scientific reports · 2024Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
It has been widely reported that intrinsic brain activity, in a variety of animals including humans, is spatiotemporally structured. Specifically, propagated slow activity has been repeatedly demonstrated in animals. In human resting-state fMRI, spontaneous activity has been understood predominantly in terms of zero-lag temporal synchrony within widely distributed functional systems (resting-state networks). Here, we use resting-state fMRI from 1,376 normal, young adults to demonstrate that multiple, highly reproducible, temporal sequences of propagated activity, which we term "lag threads," are present in the brain. Moreover, this propagated activity is largely unidirectional within conventionally understood resting-state networks. Modeling experiments show that resting-state networks naturally emerge as a consequence of shared patterns of propagation. An implication of these results is that common physiologic mechanisms may underlie spontaneous activity as imaged with fMRI in humans and slowly propagated activity as studied in animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.