Evidence map›Paper›PMID 25825707›Full record

ArticleEBioMedicine2015

Decreased

Hao Tang, Salwa Sebti, Rossella Titone, Yunyun Zhou, Ciro Isidoro, Theodora S Ross, Hanina Hibshoosh, Guanghua Xiao, Milton Packer, Yang Xie and 1 more

Open access · goldAbstract read
In one paragraph

Article in EBioMedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.

  1. Prognostic significance of autophagy-related genesThe Journal of international medical research · 2020
    Pooled it
  2. Autophagy modulation in cancer.Nature reviews. Drug discovery · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. The Biological Role and Clinical Significance of BECLIN-1 in Cancer.International journal of molecular sciences · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Advances in the study of autophagy in breast cancer.Breast cancer (Tokyo, Japan) · 2024
    Review
  18. Review
  19. Article
  20. Review

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Hao TangDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Salwa SebtiCenter for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 ; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Rossella TitoneCenter for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 ; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Yunyun ZhouDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Ciro IsidoroLaboratory of Molecular Pathology and Nanobioimaging, Department of Health Sciences, Università del Piemonte Orientale "A Avogrado", Via Solaroli 17, 28100 Novara, Italy.
Theodora S RossDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 ; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Hanina HibshooshDepartment of Pathology and Cell Biology, Columbia University College of Physicians & Surgeons, New York, New York 10032.
Guanghua XiaoDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Milton PackerDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Yang XieDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390 ; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Beth LevineCenter for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 ; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 ; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 ; Howard Hughes Medical Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
The University of Texas Southwestern Medical Center · USColumbia University · USSouthwestern Medical Center · USUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · IT

Funding

UNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI GIBBONS, DON LYNN · 1996 to 2024
$57.4M
Beclin 1-Bcl-2 Interactions: Effects on AutophagyR01CA109618 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI LEVINE, BETH C · 2004 to 2014
$3.1M
Integrative Analysis to Identify Therapeutic Targets for Lung CancerR01CA172211 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI XIAO, GUANGHUA · 2013 to 2017
$1.6M
Predicting Adjuvant Chemotherapy Response in Lung CancerR01CA152301 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI XIE, YANG · 2010 to 2014
$1.5M
NCI NIH HHS P50 CA070907NCI NIH HHS R01 CA109618NCI NIH HHS R01 CA152301NCI NIH HHS R01 CA172211
6 · The paper itself

Abstract

Both

Indexed as

autophagyBECN1BRCA1breast cancer

Identifiers

PMID25825707
PMCPMC4376376
OpenAlexW2020112232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.