Evidence map›Paper›PMID 25825652›Full record

ArticleCell & bioscience2015

Growth hormone secretagogue receptor is important in the development of experimental colitis.

Zhen-Ze Liu, Wei-Gang Wang, Qing Li, Miao Tang, Jun Li, Wen-Ting Wu, Ying-Han Wan, Zhu-Gang Wang, Shi-San Bao, Jian Fei

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Zhen-Ze LiuSchool of Life Science and Technology, Tongji University, Shanghai, 200092 China.
Wei-Gang WangShanghai Research Centre for Model Organisms, Shanghai, 201203 China.
Qing LiSchool of Life Science and Technology, Tongji University, Shanghai, 200092 China.
Miao TangSchool of Life Science and Technology, Tongji University, Shanghai, 200092 China.
Jun LiShanghai Research Centre for Model Organisms, Shanghai, 201203 China.
Wen-Ting WuShanghai Research Centre for Model Organisms, Shanghai, 201203 China.
Ying-Han WanShanghai Research Centre for Model Organisms, Shanghai, 201203 China.
Zhu-Gang WangShanghai Research Centre for Model Organisms, Shanghai, 201203 China.
Shi-San BaoDiscipline of Pathology, Bosch Institute and School of Medical Sciences, University of Sydney, Sydney, NSW 2006 Australia.
Jian FeiSchool of Life Science and Technology, Tongji University, Shanghai, 200092 China ; Shanghai Research Centre for Model Organisms, Shanghai, 201203 China.
Shanghai Model Organisms (China) · CNTongji University · CNUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGrowth hormone secretagogue receptor (GHSR) and its ligand, ghrelin, are important modulators in weight control and energy homeostasis. Recently, ghrelin is also involved in experimental colitis, but the role of GHSR in the development of colitis is unclear. The aim was to examine the underlying mechanism of GHSR in IBD development.

methodsThe temporal expression of GHSR/ghrelin was determined in dextran sulphate sodium (DSS) induced colitis in Wt mice. The severity of DSS induced colitis from GHSR(-/-) and WT mice was compared at clinical/pathological levels. Furthermore, the function of macrophages was evaluated in vivo and in vitro.

resultsLack of GHSR attenuated colitis significantly at the clinical and pathological levels with reduced colonic pro-inflammatory cytokines (P < 0.05). This is consistent with the observation of less colonic macrophage infiltration and TLRs expression from DSS-treated GHSR(-/-) mice compared to WT mice (P < 0.05). Furthermore, there was significantly reduced pro-inflammatory cytokines in LPS-stimulated macrophages in vitro from GHSR(-/-) mice than WT mice (P < 0.05). Moreover, D-lys(3)-GHRP6 (a GHSR antagonist) reduced LPS-induced macrophage pro-inflammatory cytokines from WT mice in vitro.

conclusionsGHSR contributes to development of acute DSS-induced colitis, likely via elevated pro-inflammatory cytokines and activation of macrophages. These data suggest GHSR as a potential therapeutic target for IBD.

Indexed as

ColitisD-lys3-GHRP6GhrelinGrowth hormone secretagogue receptor (GHSR)Macrophages

Identifiers

PMID25825652
PMCPMC4377856
OpenAlexW2165436611

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.