Evidence map›Paper›PMID 25825600›Full record

ArticleTheranostics2015

Charge and hydrophobicity effects of NIR fluorophores on bone-specific imaging.

Kai Bao, Khaled A Nasr, Hoon Hyun, Jeong Heon Lee, Julien Gravier, Summer L Gibbs, Hak Soo Choi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 53 citations in OpenAlex.

  1. More Than a Glow: How Cyanine Dyes Shape Tracer Pharmacokinetics.Angewandte Chemie (International ed. in English) · 2026
    Review
  2. Review: structural determinants of organic dyes for controlling biological clearance pathways.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Review
  3. Tissue-seeking dyes for in vivo applications.Smart molecules : open access · 2024
    Review
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  18. Precise Diagnosis and Therapy of Bone Cancer Using Near-Infrared Lights.Frontiers in bioengineering and biotechnology · 2021
    Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Kai Bao1. Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215; ; 2. Key Laboratory of Structure-based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China, 110016;
Khaled A Nasr1. Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215; ; 3. Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390;
Hoon Hyun1. Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215;
Jeong Heon Lee1. Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215;
Julien Gravier1. Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215;
Summer L Gibbs4. Department of Biomedical Engineering, OHSU Center for Spatial Systems Biology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97201.
Hak Soo Choi1. Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215;
Beth Israel Deaconess Medical Center · US

Funding

Image-Guided Surgery of Endocrine Glands and Their Tumors using Near-Infrared FluR01EB011523 · NIBIB · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHOI, HAK SOO · 2010 to 2013
$2.0M
NIBIB NIH HHS R01 EB011523NIBIB NIH HHS R01-EB-011523
6 · The paper itself

Abstract

Recent advances in near-infrared (NIR) fluorescence imaging enabled real-time intraoperative detection of bone metastases, bone growth, and tissue microcalcification. Pamidronate (PAM) has been widely used for this purpose because of its high binding affinity toward bone and remarkable therapeutic effects. Herein we describe the development of a series of PAM-conjugated NIR fluorophores that varied in net charges and hydrophobicity, and compared their bone targeting efficiency, biodistribution, and blood clearance. Since the targeting moiety, PAM, is highly negatively charged but small, the overall in vivo bone targeting and biodistribution were mediated by the physicochemical properties of conjugated fluorophores.

Indexed as

AnimalsBone and BonesCalcinosisDiphosphonatesFemaleFluorescent DyesHydrophobic and Hydrophilic InteractionsMicePamidronateSpectroscopy, Near-InfraredStatic ElectricityTissue DistributionDiphosphonatesFluorescent DyesPamidronateBone targetingCharge and hydrophobicityMicrocalcificationNear-infrared fluorophoresZwitterionic fluorophores.

Identifiers

PMID25825600
PMCPMC4377729
OpenAlexW2114962100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.