Evidence map›Paper›PMID 25825543›Full record

ArticlePhysiological reports2015

A novel cardiac muscle-derived biomaterial reduces dyskinesia and postinfarct left ventricular remodeling in a mouse model of myocardial infarction.

Daniel M O'Connor, Nivedita K Naresh, Bryan A Piras, Yaqin Xu, Robert S Smith, Frederick H Epstein, John A Hossack, Roy C Ogle, Brent A French

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. [Present status and prospects of injectable hydrogels for treatment of myocardial infarction].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2017
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Daniel M O'ConnorDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.
Nivedita K NareshDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.
Bryan A PirasDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.
Yaqin XuDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.
Robert S SmithDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.
Frederick H EpsteinDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia Department of Radiology, University of Virginia, Charlottesville, Virginia.
John A HossackDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.
Roy C OgleSchool of Medical Diagnostic and Translational Sciences, College of Health Sciences, Old Dominion University, Norfolk, Virginia.
Brent A FrenchDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia Department of Radiology, University of Virginia, Charlottesville, Virginia bf4g@virginia.edu.
University of Virginia · USOld Dominion University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular matrix (ECM) degradation after myocardial infarction (MI) leaves the myocardium structurally weakened and, as a result, susceptible to early infarct zone dyskinesia and left ventricular (LV) remodeling. While various cellular and biomaterial preparations have been transplanted into the infarct zone in hopes of improving post-MI LV remodeling, an allogeneic cardiac muscle-derived ECM extract has yet to be developed and tested in the setting of reperfused MI. We sought to determine the effects of injecting a novel cardiac muscle-derived ECM into the infarct zone on early dyskinesia and LV remodeling in a mouse model of MI. Cardiac muscle ECM was extracted from frozen mouse heart tissue by a protocol that enriches for basement membrane constituents. The extract was injected into the infarct zone immediately after ischemia/reperfusion injury (n = 6). Echocardiography was performed at baseline and at days 2, 7, 14, and 28 post-MI to assess 3D LV volumes and cardiac function, as compared to infarcted controls (n = 9). Early infarct zone dyskinesia was measured on day 2 post-MI using a novel metric, the dyskinesia index. End-systolic volume was significantly reduced in the ECM-treated group compared to controls by day 14. Ejection fraction and stroke volume were also significantly improved in the ECM-treated group. ECM-treated hearts showed a significant (P < 0.005) reduction in dyskinetic motion on day 2. Thus, using high-frequency ultrasound, it was shown that treatment with a cardiac-derived ECM preparation reduced early infarct zone dyskinesia and post-MI LV remodeling in a mouse model of reperfused MI.

Indexed as

Extracellular matrixleft ventricular remodelingmyocardial infarctionsmall animal imagingspeckle tracking echocardiography

Identifiers

PMID25825543
PMCPMC4393176
OpenAlexW2155397682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.