Evidence map›Paper›PMID 25825520›Full record

ReviewJournal of pediatric psychology

Topical Review: The Emerging Field of Epigenetics: Informing Models of Pediatric Trauma and Physical Health.

Nicole R Nugent, Amy Goldberg, Monica Uddin

Abstract readReview
In one paragraph

Review in Journal of pediatric psychology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  4. Review
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nicole R NugentDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School at Brown University, Bradley Hasbro Research Center, Rhode Island Hospital, nicole_nugent@brown.edu.
Amy GoldbergDepartment of Pediatrics, Warren Alpert Medical School at Brown University, Lawrence A. Aubin Sr. Child Protection Center, Hasbro Children's Hospital and.
Monica UddinDepartment of Psychology and Carl W. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign.

Funding

Biomarkers, Social and Affective Predictors of Suicidal Thoughts and Behaviors in AdolescentsR01MH105379 · NIMH · RHODE ISLAND HOSPITAL · PI NUGENT, NICOLE R · 2015 to 2019
$3.3M
Multi-Method Assessment of Emotion Reactivity: Translational Research in SuicideR01MH095786 · NIMH · BUTLER HOSPITAL (PROVIDENCE, RI) · PI ARMEY, MICHAEL F, MILLER, IVAN W. · 2012 to 2016
$2.3M
Mechanisms of Intergenerational Impact of Maternal TraumaR01HD071982 · NICHD · EMORY UNIVERSITY · PI BRADLEY, BEKH · 2013 to 2017
$2.1M
Psychogenetic Factors in Project REACHK01MH087240 · NIMH · RHODE ISLAND HOSPITAL · PI NUGENT, NICOLE R · 2009 to 2013
$760k
NICHD NIH HHS R01 HD071982NIMH NIH HHS K01 MH087240NIMH NIH HHS R01 MH095786NIMH NIH HHS R01MH095786NIMH NIH HHS R01 MH105379NIMH NIH HHS R01MH105379
6 · The paper itself

Abstract

objectiveTrauma experienced during childhood and adolescence has been linked to a number of chronic medical concerns. We highlight major findings from the pediatric trauma literature to provide a model for understanding this association.

methodsStudies examining the effects of trauma were systematically reviewed and synthesized into a model proposing a central role for epigenetics in the ways that childhood experiences can affect health.

resultsEarly hypothalamic pituitary adrenal (HPA) axis response may impact initial trauma experience, with downstream effects on posttrauma adjustment reflected in posttrauma neurobiology, psychological health, and physical health.

conclusionsProspective research with children and adolescents exposed to trauma is needed to better characterize the genetic and epigenetic influences on the course of HPA and immune processes as related to posttrauma psychological and physical health outcomes.

Indexed as

Child AbuseEpigenesis, GeneticAdolescentChildHumansHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemPsychological Traumaadjustmentgenetics and genetic disordersposttraumatic stress

Identifiers

PMID25825520
PMCPMC4902862

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.