Evidence map›Paper›PMID 25825435›Full record

ArticleJournal of bacteriology2015

Regulation by the modulation of gene expression variability.

David Dubnau

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

David DubnauPublic Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA dubnauda@njms.rutgers.edu.
Rutgers, The State University of New Jersey · US

Funding

The Role of Polyadenylation in RNA TurnoverR01GM057220 · NIGMS · UNIVERSITY OF GEORGIA (UGA) · PI KUSHNER, SIDNEY R. · 1999 to 2012
$3.5M
The Role of Polyadenylation in RNA TurnoverR56GM057220 · NIGMS · UNIVERSITY OF GEORGIA · PI KUSHNER, SIDNEY R. · 2007 to 2007
$348k
NIGMS NIH HHS GM057220NIGMS NIH HHS R01 GM057220NIGMS NIH HHS R56 GM057220
6 · The paper itself

Abstract

Classically, transcription is regulated so that the average expression per cell changes, often with a distribution that extends across the population. Roggiani and Goulian (M. Roggiani and M. Goulian, J. Bacteriol. 197:1976-1987, 2015, doi:http://dx.doi.org/10.1128/JB.00074-15) have shown that this is what happens when the torCAD operon of Escherichia coli is induced anaerobically by the addition of trimethylamine-N-oxide (TMAO). However, when the same inducer is added to aerobically growing cells, only a subset of the cells respond, although the mean expression per cell is similar to that obtained anaerobically. Thus, in the presence of oxygen, the variance but not the expression mean is altered. The regulation of gene expression variance appears to be due to noise in the phosphorelay that governs torCAD transcription.

Indexed as

Escherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialOxygenSignal TransductionTranscription, GeneticEscherichia coli ProteinsOxygen

Identifiers

PMID25825435
PMCPMC4438217
OpenAlexW2035797441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.