Evidence map›Paper›PMID 25825402›Full record

ArticleCirculation2015

Cardiology patient page. Statin intolerance.

David H Fitchett, Robert A Hegele, Subodh Verma

Registry-linked trialAbstract readPatient Education Handout
PubMed Publisher
In one paragraph

Article in Circulation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06381947 (Efficacy and Safety of Bempedoic Acid in Association With Anti-PCSK9 and Ezetimibe in Statin-intolerant Patients), which is not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06381947 phase4unknown statusstarted 2024, after this paper: background citation

Efficacy and Safety of Bempedoic Acid in Association With Anti-PCSK9 and Ezetimibe in Statin-intolerant Patients: a Randomized Crossover Trial

Ran2024Enrolled130Registered outcomes19Posted comparisons0ConditionsCardiovascular Diseases, Dyslipidemias, Lipid Metabolism Disorders, Statin Adverse ReactionArmsLipid-lowering therapy combination with PCSK9 inhibitors and ezetimibe, Lipid-lowering therapy combination with PCSK9 inhibitors, bempedoic acid and ezetimibe
PMID 26030325PMID 30662020PMID 26638010PMID 25687353PMID 26027630PMID 27892461PMID 16424354PMID 19768174PMID 26687696PMID 27039291PMID 27668060PMID 29910030other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Therapeutic Antibodies in Medicine.Molecules (Basel, Switzerland) · 2023
    Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David H FitchettFrom Divisions of Cardiology (D.H.F.) and Cardiac Surgery (S.V.), Li Ka Shing Knowledge Institute (D.H.F., S.V.) and Keenan Research Centre for Biomedical Science (S.V.), St. Michael's Hospital, Toronto, ON, Canada; Departments of Medicine (D.H.F.) and Surgery (S.V.), University of Toronto, ON, Canada; and Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada (R.A.H.).
Robert A HegeleFrom Divisions of Cardiology (D.H.F.) and Cardiac Surgery (S.V.), Li Ka Shing Knowledge Institute (D.H.F., S.V.) and Keenan Research Centre for Biomedical Science (S.V.), St. Michael's Hospital, Toronto, ON, Canada; Departments of Medicine (D.H.F.) and Surgery (S.V.), University of Toronto, ON, Canada; and Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada (R.A.H.).
Subodh VermaFrom Divisions of Cardiology (D.H.F.) and Cardiac Surgery (S.V.), Li Ka Shing Knowledge Institute (D.H.F., S.V.) and Keenan Research Centre for Biomedical Science (S.V.), St. Michael's Hospital, Toronto, ON, Canada; Departments of Medicine (D.H.F.) and Surgery (S.V.), University of Toronto, ON, Canada; and Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada (R.A.H.). vermasu@smh.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cardiovascular DiseasesChemical and Drug Induced Liver InjuryCholesterol, LDLDiabetes Mellitus, Type 2Diet, Fat-RestrictedDrug SubstitutionEvidence-Based MedicineHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypercholesterolemiaLiver Function TestsLongevityMyalgiaRhabdomyolysisRisk FactorsCholesterol, LDLHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID25825402

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.