ReviewNestle Nutrition Institute workshop series2012
Vitamin A supplementation, infectious disease and child mortality: a summary of the evidence.
Review in Nestle Nutrition Institute workshop series, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Review
- The role of retinoic acid in the production of immunoglobulin A.Mucosal immunology · 2022Review
- Role of Vitamin A Supplementation in Prevention and Control of Coronavirus Disease-19: A Narrative Review.International journal of preventive medicine · 2022Review
- Clickable Vitamins as a New Tool to Track Vitamin A and Retinoic Acid in Immune Cells.Frontiers in immunology · 2021Article
- Vitamin A and retinoic acid combined have a more potent effect compared to vitamin A alone on the uptake of retinol into extrahepatic tissues of neonatal rats raised under vitamin A-marginal conditions.Current developments in nutrition · 2017Article
- Vitamin A supplementation redirects the flow of retinyl esters from peripheral to central organs of neonatal rats raised under vitamin A-marginal conditions.The American journal of clinical nutrition · 2017Article
- Association between serum vitamin D, retinol and zinc status, and acute respiratory infections in underweight and normal-weight children aged 6-24 months living in an urban slum in Bangladesh.Epidemiology and infection · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This manuscript reviews the evidence related to the effects of vitamin A (VA) supplementation of women and children on child health and mortality. VA supplementation of children aged 6-59 months has been well studied, and meta-analyses have consistently demonstrated effects on all-cause mortality, yet its mechanisms and the reasons for heterogeneous effects on mortality across trials continue to be debated. Recent meta-analysis of cause-specific mortality suggests beneficial effects on diarrheal mortality, with null but potentially beneficial effects also present for mortality from measles, lower respiratory infection, and meningitis. Some evidence suggests that pneumonia severity may increase with VA supplementation in this age group, particularly among well-nourished children. Maternal supplementation with VA during pregnancy has not shown benefits on neonatal mortality in large trials. A recent meta-analysis suggested that high-dose supplementation of lactating women immediately following delivery did not affect child survival. There is still uncertainty around the benefits of neonatal VA supplementation that should be resolved once the findings of ongoing trials are reported.
Indexed as
Identifiers
25825298What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.