ArticleJournal of proteome research2015
Developmental Changes for the Hemolymph Metabolome of Silkworm (Bombyx mori L.).
Article in Journal of proteome research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Transcriptome analysis of perforated small cocoon from Bombyx mori mutants.Scientific reports · 2026Article
- The platelet concentrate storage environment may enhance the ability of Cutibacterium acnes to establish chronic infections.Transfusion · 2025Article
- Comparative transcriptome analysis of midgut of Bombyx mori under a sucrose-supplemented diet.Scientific reports · 2025Article
- 20-Hydroxyecdysone Regulates the Expression of 30 Genes Specifically Expressed in Larval Digestive Tube of the Silkworm,Insects · 2025Article
- Proteomic Analysis of Midgut of Silkworm Reared on Artificial Diet and Mulberry Leaves and Functional Study of ThreeInternational journal of molecular sciences · 2025Article
- Transcriptome and Metabolome Analysis ofGenes · 2024Article
- Article
- Honey Bee Larval Hemolymph as a Source of Key Nutrients and Proteins Offers a Promising Medium forInternational journal of molecular sciences · 2023Article
- SericinInsects · 2023Article
- Metabolite Changes in Orange Dead Leaf ButterflyMetabolites · 2022Article
- Multi-tissue metabolomic profiling reveals potential mechanisms of cocoon yield in silkworms (Frontiers in molecular biosciences · 2022Article
- Article
- Evaluation of the Metabolic Effects of Hydrogen Sulfide on the Development of Bombyx mori (Lepidoptera: Bombycidae), Using Liquid Chromatography-Mass Spectrometry-Based Metabolomics.Journal of insect science (Online) · 2020Article
- iTRAQ-Based Quantitative Proteomic Analysis of Digestive Juice across the First 48 Hours of the Fifth Instar in Silkworm Larvae.International journal of molecular sciences · 2019Article
- Silkworm, Bombyx mori, as an alternative model organism in toxicological research.Environmental science and pollution research international · 2018Article
- Bm-iAANAT and its potential role in fatty acid amide biosynthesis in Bombyx mori.Prostaglandins, leukotrienes, and essential fatty acids · 2018Article
- Metabolomics differences between silkworms (Bombyx mori) reared on fresh mulberry (Morus) leaves or artificial diets.Scientific reports · 2017Article
- Simultaneous Quantification of Amino Metabolites in Multiple Metabolic Pathways Using Ultra-High Performance Liquid Chromatography with Tandem-mass Spectrometry.Scientific reports · 2017Article
- Metabolomics Analysis of the Larval Head of the Silkworm, Bombyx mori.International journal of molecular sciences · 2016Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Silkworm (Bombyx mori) is a lepidopteran-holometabolic model organism. To understand its developmental biochemistry, we characterized the larval hemolymph metabonome from the third instar to prepupa stage using (1)H NMR spectroscopy whilst hemolymph fatty acid composition using GC-FID/MS. We unambiguously assigned more than 60 metabolites, among which tyrosine-o-β-glucuronide, mesaconate, homocarnosine, and picolinate were reported for the first time from the silkworm hemolymph. Phosphorylcholine was the most abundant metabolite in all developmental stages with exception for the periods before the third and fourth molting. We also found obvious developmental dependence for the hemolymph metabonome involving multiple pathways including protein biosyntheses, glycolysis, TCA cycle, the metabolisms of choline amino acids, fatty acids, purines, and pyrimidines. Most hemolymph amino acids had two elevations during the feeding period of the fourth instar and prepupa stage. Trehalose was the major blood sugar before day 8 of the fifth instar, whereas glucose became the major blood sugar after spinning. C16:0, C18:0 and its unsaturated forms were dominant fatty acids in hemolymph. The developmental changes of hemolymph metabonome were associated with dietary nutrient intakes, biosyntheses of cell membrane, pigments, proteins, and energy metabolism. These findings offered essential biochemistry information in terms of the dynamic metabolic changes during silkworm development.
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