Evidence map›Paper›PMID 25825122›Full record

ArticleDrugs & aging2015

Sulfonylurea use and risk of hip fractures among elderly men and women with type 2 diabetes.

Swapnil N Rajpathak, Chunmay Fu, Kimberly G Brodovicz, Samuel S Engel, Kate Lapane

Abstract read
PubMed Publisher
In one paragraph

Article in Drugs & aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 4 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Influence of glycemic control and hypoglycemia on the risk of fracture in patients with diabetes mellitus: a systematic review and meta-analysis of observational studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Role of microRNA in Diabetic Osteoporosis.Molecular biotechnology · 2025
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Effect of type 2 diabetes medications on fracture risk.Annals of translational medicine · 2019
    Review
  14. Bone health in diabetes and prediabetes.World journal of diabetes · 2019
    Review
  15. Diabetes and bone.Osteoporosis and sarcopenia · 2019
    Review
  16. Diabetes pharmacotherapy and effects on the musculoskeletal system.Diabetes/metabolism research and reviews · 2019
    Review
  17. Skeletal Fragility in Type 2 Diabetes Mellitus.Endocrinology and metabolism (Seoul, Korea) · 2018
    Review
  18. Real-world antidiabetic drug use and fracture risk in 12,277 patients with type 2 diabetes mellitus: a nested case-control study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018 · on this map
    Observational
  19. Observational
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Swapnil N RajpathakCenter for Observational and Real-World Evidence, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, USA, swapnil.rajpathak@merck.com.
Chunmay Fu
Kimberly G Brodovicz
Samuel S Engel
Kate Lapane
Merck & Co., Inc., Rahway, NJ, USA (United States) · USUniversity of Massachusetts Chan Medical School · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBoth increased age and type 2 diabetes mellitus are risk factors for developing bone fractures. While recent data in the elderly suggest a link between hypoglycemia and fall-related fractures, the association between sulfonylureas, commonly used hypoglycemic agents, and fracture risk has not been well investigated.

methodsWe used patient data from a large commercial health insurer from 2002-2005. Individuals aged ≥65 years receiving oral sulfonylurea treatment (n=13,195) were matched 1:1 to non-users based on propensity for sulfonylurea use. Multivariable conditional logistic regression was used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CIs).

resultsDuring an average 4 years of follow-up, sulfonylurea users experienced 226 incident hip fractures (1.7%) and non-users experienced 157 (1.2%). Sulfonylurea use was associated with increased risk of developing hip fracture (aOR 1.46, 95% CI 1.17-1.82), and this association was apparent for men (120 cases; aOR 1.83, 95% CI 1.25-2.66) and women (263 cases; aOR 1.32, 95% CI 1.03-1.69). Patients with documented hypoglycemia in the follow-up period had increased odds of hip fracture relative to those without such diagnosis (aOR 2.42, 95% CI 1.35-4.34).

conclusionSulfonylureas are associated with increased risk of hip fracture in elderly men and women with type 2 diabetes.

Indexed as

AgedAged, 80 and overDiabetes Mellitus, Type 2FemaleFollow-Up StudiesHip FracturesHumansHypoglycemiaHypoglycemic AgentsMaleRetrospective StudiesRisk FactorsSulfonylurea CompoundsHypoglycemic AgentsSulfonylurea Compounds

Identifiers

PMID25825122
OpenAlexW2001033822

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.