ArticleInfection and immunity2015
Listeria monocytogenes spreads within the brain by actin-based intra-axonal migration.
Article in Infection and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Early trigeminal nerve involvement in Listeria monocytogenes rhombencephalitis: case series and systematic review.Journal of neurology · 2017Pooled it
- Divergent host-pathogen interactions in neurolisteriosis: cytosolic replication vs. phagosomal dormancy of Listeria monocytogenes in CNS macrophages.Acta neuropathologica · 2025Article
- Liposomal Nanotraps NeutralizeInfectious microbes & diseases · 2025Article
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- Neurological and immunological characteristics of a novel immortalized bovine brainstem-derived cell line and its susceptibility to arbovirus infection.Frontiers in cellular and infection microbiology · 2025Article
- Replication of Akabane virus and related orthobunyaviruses in a fetal-bovine-brain-derived cell line.Archives of virology · 2024Article
- Listeria brain abscess: a therapeutically challenging rare presentation of listeriosis.BMC infectious diseases · 2024Article
- Computed tomography and magnetic resonance imaging findings in central nervous system listeriosis.Neuroradiology · 2024Article
- Temporal and spatial dynamics ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- White Matter Spreading MRI Pattern ofNeurology · 2023Article
- Article
- Human Listeriosis.Clinical microbiology reviews · 2023Review
- Cerebral abscess due toIDCases · 2023Article
- Bovine neutrophil chemotaxis to Listeria monocytogenes in neurolisteriosis depends on microglia-released rather than bacterial factors.Journal of neuroinflammation · 2022Article
- Safety of a NovelFrontiers in cellular and infection microbiology · 2021Article
- Neurotropic Lineage III Strains of Listeria monocytogenes Disseminate to the Brain without Reaching High Titer in the Blood.mSphere · 2020Article
- The olfactory epithelium as a port of entry in neonatal neurolisteriosis.Nature communications · 2018Article
- Listeria monocytogenes Infection of the Brain.Journal of visualized experiments : JoVE · 2018Article
- Histopathology of Listeria Meningitis.Journal of neuropathology and experimental neurology · 2018Article
- The Tunnel Sign Revisited: A Novel Observation of Cerebral Melioidosis Mimicking Sparganosis.Journal of radiology case reports · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Listeria monocytogenes rhombencephalitis is a severe progressive disease despite a swift intrathecal immune response. Based on previous observations, we hypothesized that the disease progresses by intra-axonal spread within the central nervous system. To test this hypothesis, neuroanatomical mapping of lesions, immunofluorescence analysis, and electron microscopy were performed on brains of ruminants with naturally occurring rhombencephalitis. In addition, infection assays were performed in bovine brain cell cultures. Mapping of lesions revealed a consistent pattern with a preferential affection of certain nuclear areas and white matter tracts, indicating that Listeria monocytogenes spreads intra-axonally within the brain along interneuronal connections. These results were supported by immunofluorescence and ultrastructural data localizing Listeria monocytogenes inside axons and dendrites associated with networks of fibrillary structures consistent with actin tails. In vitro infection assays confirmed that bacteria were moving within axon-like processes by employing their actin tail machinery. Remarkably, in vivo, neutrophils invaded the axonal space and the axon itself, apparently by moving between split myelin lamellae of intact myelin sheaths. This intra-axonal invasion of neutrophils was associated with various stages of axonal degeneration and bacterial phagocytosis. Paradoxically, the ensuing adaxonal microabscesses appeared to provide new bacterial replication sites, thus supporting further bacterial spread. In conclusion, intra-axonal bacterial migration and possibly also the innate immune response play an important role in the intracerebral spread of the agent and hence the progression of listeric rhombencephalitis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.