ArticleGenes, brain, and behavior2015
SERT and uncertainty: serotonin transporter expression influences information processing biases for ambiguous aversive cues in mice.
Article in Genes, brain, and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Safety in treatment: Classical pharmacotherapeutics and new avenues for addressing maternal depression and anxiety during pregnancy.Pharmacological reviews · 2025Review
- More and Less Fear in Serotonin Transporter Knockout Mice.Genes, brain, and behavior · 2025Article
- α2-containing γ-aminobutyric acid type A receptors promote stress resiliency in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- A prefrontal-bed nucleus of the stria terminalis circuit limits fear to uncertain threat.eLife · 2020Article
- Functional Divergence of Mammalian TFAP2a and TFAP2b Transcription Factors for Bidirectional Sleep Control.Genetics · 2020Article
- Vesicular monoamine transporter 2 mediates fear behavior in mice.Genes, brain, and behavior · 2020Article
- A neuroeconomic investigation ofAnxiety, stress, and coping · 2020Article
- Enhanced discriminative aversive learning and amygdala responsivity in 5-HT transporter mutant mice.Translational psychiatry · 2019Article
- Article
- A genetic reduction in the serotonin transporter differentially influences MDMA and heroin induced behaviours.Psychopharmacology · 2018Article
- Emergence in extinction of enhanced and persistent responding to ambiguous aversive cues is associated with high MAOA activity in the prelimbic cortex.Neurobiology of stress · 2016Article
- Serotonin, Amygdala and Fear: Assembling the Puzzle.Frontiers in neural circuits · 2016Review
- Serotonin, neural markers, and memory.Frontiers in pharmacology · 2015Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The long allele variant of the serotonin transporter (SERT, 5-HTT) gene-linked polymorphic region (5-HTTLPR) is associated with higher levels of 5-HTT expression and reduced risk of developing affective disorders. However, little is known about the mechanisms underlying this protective effect. One hypothesis is that 5-HTT expression influences aversive information processing, with reduced negative cognitive bias present in those with higher 5-HTT expression. Here we investigated this hypothesis using genetically-modified mice and a novel aversive learning paradigm. Mice with high levels of 5-HTT expression (5-HTT over-expressing, 5-HTTOE mice) and wild-type mice were trained to discriminate between three distinct auditory cues: one cue predicted footshock on all trials (CS+); a second cue predicted the absence of footshock (CS-); and a third cue predicted footshock on 20% of trials (CS20%), and was therefore ambiguous. Wild-type mice exhibited equivalently high levels of fear to the CS+ and CS20% and minimal fear to the CS-. In contrast, 5-HTTOE mice exhibited high levels of fear to the CS+ but minimal fear to the CS- and the CS20%. This selective reduction in fear to ambiguous aversive cues suggests that increased 5-HTT expression reduces negative cognitive bias for stimuli with uncertain outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.