Evidence map›Paper›PMID 25824451›Full record

ArticleAmerican journal of hypertension2015

Blood Pressure Reactivity to the Cold Pressor Test Predicts Hypertension Among Chinese Adults: The GenSalt Study.

Qi Zhao, Dongfeng Gu, Fanghong Lu, Jianjun Mu, Xushan Wang, Xu Ji, Dongsheng Hu, Jixiang Ma, Jianfeng Huang, Jianxin Li and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Early sympathetic neural responses during a cold pressor test linked to pain perception.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Article
  8. Article
  9. Article
  10. Observational
  11. Acute Effects of Moderate Continuous Training on Stress Test-Related Pulse Pressure and Wave Reflection in Healthy Men.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 2 countries.

Qi ZhaoDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA; qizhao@tulane.edu.
Dongfeng GuState Key Laboratory of Cardiovascular Disease and Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;
Fanghong LuInstitute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong, China;
Jianjun MuFirst Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China;
Xushan WangCenter for Disease Control and Prevention of Ganyu County, Ganyu, Jiangsu, China;
Xu JiXinle Traditional Medicine Hospital, Xinle, Hebei, China;
Dongsheng HuShenzhen University Medical Center, Shenzhen, Guangdong, China;
Jixiang MaNational Center for Chronic and Non-communicable Disease Control and Prevention, China CDC, Beijing, China;
Jianfeng HuangState Key Laboratory of Cardiovascular Disease and Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;
Jianxin LiState Key Laboratory of Cardiovascular Disease and Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;
Jichun ChenState Key Laboratory of Cardiovascular Disease and Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;
Jie CaoState Key Laboratory of Cardiovascular Disease and Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;
Chung-Shiuan ChenDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA;
Jing ChenDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA;
Treva K RiceDivision of Biostatistics, Washington University School of Medicine, St Louis, Missouri, USA.
Jiang HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA;
Chinese Academy of Medical Sciences & Peking Union Medical College · CNTulane University · USCenters for Disease Control and Prevention · USFirst Affiliated Hospital of Xi'an Jiaotong University · CNHospital of Hebei Province · CNNational Center for Chronic and Noncommunicable Disease Control and Prevention · CNShandong First Medical University · CNShenzhen University · CNWashington University in St. Louis · US

Funding

Tulane Building Interdisciplinary Research Careers in Women's Health (BIRCWH)K12HD043451 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI KROUSEL-WOOD, MARIE · 2002 to 2023
$9.9M
Sodium Sensitivity and Risk of HypertensionR01HL087263 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2007 to 2011
$2.8M
Research Training in Gene-Environment Interaction in ChinaD43TW009107 · FIC · TULANE UNIVERSITY OF LOUISIANA · PI GU, DONGFENG, HE, JIANG · 2012 to 2016
$1.1M
FIC NIH HHS D43 TW009107NHLBI NIH HHS R01 HL087263NICHD NIH HHS K12 HD043451NICHD NIH HHS K12HD043451
6 · The paper itself

Abstract

backgroundBlood pressure (BP) hyper-reactivity to the cold pressor test (CPT) has been suggested as a predictor of hypertension. We examined whether BP reactivity to the CPT was associated with hypertension incidence among the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) study participants from China.

methodsA total of 1,961 GenSalt study participants without any antihypertensive treatment completed the CPT at the baseline examination. Hypertension status was assessed at baseline (2003-2005) and 2 follow-up visits (2008-2009 and 2011-2012).

resultsAfter adjustment for multiple covariates, both systolic BP (SBP) and diastolic BP reactivity to the CPT were significantly associated with hypertension incidence. For example, the multivariable adjusted odds ratios (ORs, 95% CI) of developing hypertension were 0.92 (0.66, 1.29), 1.42 (1.03, 1.97), and 1.45 (1.05, 2.00) for participants with maximum SBP responses of 6.7-12.0, 12.1-19.2, and ≥19.3mm Hg, respectively, compared to those with responses of <6.7mm Hg (P for trend = 0.006). Likewise, the multivariable-adjusted ORs (95% CI) of hypertension were 1.12 (0.79, 1.57), 1.62 (1.15, 2.29), and 1.82 (1.30, 2.55) for participants with the area under the curve of SBP responses of 3.0-16.0, 16.1-29.9, and ≥ 30.0mm Hg·min, respectively, compared to those with responses of < 3.0mm Hg·min (P for trend = 0.0001). The associations between BP reactivity variables and the risk of hypertension were not different among subgroups of sex, age, and baseline BP levels.

conclusionsBP hyperreactivity to the cold stimulus may predict the risk of hypertension among Chinese adults.

Indexed as

Cold TemperatureHypertensionBlood PressureFemaleHemodynamicsHumansMaleMiddle AgedPhysical StimulationPredictive Value of TestsPressurePrognosisRisk FactorsSympathetic Nervous Systemblood pressurehypertensionrisk factorsstresssympathetic nervous system.

Identifiers

PMID25824451
PMCPMC4612341
OpenAlexW2086927468

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.