Evidence map›Paper›PMID 25824304›Full record

ArticleMolecular psychiatry2016

Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa.

P B Shih, J Yang, C Morisseau, J B German, A A Scott-Van Zeeland, A M Armando, O Quehenberger, A W Bergen, P Magistretti, W Berrettini and 4 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03100656 (Solving EPHX2 and Polyunsaturated Fatty Acid Interactions in Anorexia Nervosa), which is not on this map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03100656 narecruitingnot on this map

Solving EPHX2 and Polyunsaturated Fatty Acid Interactions in Anorexia Nervosa

TypeinterventionalSponsorUniversity of California, San DiegoRan2016 to 2027Enrolled300ConditionsAnorexia NervosaArmsA breakfast sandwich
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Recovery From Anorexia Nervosa: A Concept Analysis.Journal of advanced nursing · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Ovarian hormones and eating disorders.Frontiers in psychology · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

P B ShihDepartment of Psychiatry, University of California at San Diego, San Diego, CA, USA.
J YangDepartment of Entomology, University of California at Davis, Davis, CA, USA.
C MorisseauDepartment of Entomology, University of California at Davis, Davis, CA, USA.
J B GermanDepartment of Entomology, University of California at Davis, Davis, CA, USA.
A A Scott-Van ZeelandCypher Genomics, San Diego, CA, USA.
A M ArmandoDepartment of Psychiatry, University of California at San Diego, San Diego, CA, USA.
O QuehenbergerDepartment of Psychiatry, University of California at San Diego, San Diego, CA, USA.
A W BergenCenter for Health Sciences, SRI International, Menlo Park, CA, USA.
P MagistrettiDivision of Biological and Environmental Sciences and Engineering, KAUST, Thuwal, KSA and Brain Mind Institute, EPFL, Lausanne, Switzerland.
W BerrettiniDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
K A HalmiDepartment of Psychiatry, Cornell University, New York, NY, USA.
N SchorkDepartment of Human Biology, J. Craig Venter Institute, San Diego, CA, USA.
B D HammockDepartment of Entomology, University of California at Davis, Davis, CA, USA.
W KayeDepartment of Psychiatry, University of California at San Diego, San Diego, CA, USA.
University of California, Davis · USUniversity of California, San Diego · USCornell University · USÉcole Polytechnique Fédérale de Lausanne · CHJ. Craig Venter Institute · USSRI International · USUniversity of Pennsylvania · US

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 1987 to 2021
$50.1M
West Coast Central Comprehensive Metabolomics Resource Core (WC3MRC)U24DK097154 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2012 to 2017
$9.9M
HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINSR01ES002710 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1985 to 2018
$4.0M
Solving EPHX2 and PUFA Interactions in Anorexia NervosaR01MH106781 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHIH, PEI-AN (BETTY) · 2016 to 2020
$2.0M
Genetic Study of PP-Fold Polypeptide-Receptor Axis on Metabolic Syndrome RiskK01DK087813 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHIH, PEI-AN (BETTY) · 2011 to 2014
$544k
NIDDK NIH HHS 1K01DK087813-01A1NIDDK NIH HHS K01 DK087813NIDDK NIH HHS U24 DK097154NIDDK NIH HHS U24DK097154NIEHS NIH HHS P42 ES004699NIEHS NIH HHS R01 ES002710NIMH NIH HHS R01 MH106781
6 · The paper itself

Abstract

Individuals with anorexia nervosa (AN) restrict eating and become emaciated. They tend to have an aversion to foods rich in fat. Because epoxide hydrolase 2 (EPHX2) was identified as a novel AN susceptibility gene, and because its protein product, soluble epoxide hydrolase (sEH), converts bioactive epoxides of polyunsaturated fatty acid (PUFA) to the corresponding diols, lipidomic and metabolomic targets of EPHX2 were assessed to evaluate the biological functions of EPHX2 and their role in AN. Epoxide substrates of sEH and associated oxylipins were measured in ill AN, recovered AN and gender- and race-matched controls. PUFA and oxylipin markers were tested as potential biomarkers for AN. Oxylipin ratios were calculated as proxy markers of in vivo sEH activity. Several free- and total PUFAs were associated with AN diagnosis and with AN recovery. AN displayed elevated n-3 PUFAs and may differ from controls in PUFA elongation and desaturation processes. Cytochrome P450 pathway oxylipins from arachidonic acid, linoleic acid, alpha-linolenic acid and docosahexaenoic acid PUFAs are associated with AN diagnosis. The diol:epoxide ratios suggest the sEH activity is higher in AN compared with controls. Multivariate analysis illustrates normalization of lipidomic profiles in recovered ANs. EPHX2 influences AN risk through in vivo interaction with dietary PUFAs. PUFA composition and concentrations as well as sEH activity may contribute to the pathogenesis and prognosis of AN. Our data support the involvement of EPHX2-associated lipidomic and oxylipin dysregulations in AN, and reveal their potential as biomarkers to assess responsiveness to future intervention or treatment.

Indexed as

AdolescentAdultAnorexia NervosaCase-Control StudiesCross-Sectional StudiesDietEpoxide HydrolasesFatty Acids, UnsaturatedFemaleGenetic Predisposition to DiseaseHumansLipid MetabolismOxylipinsEPHX2 protein, humanEpoxide HydrolasesFatty Acids, UnsaturatedOxylipins

Identifiers

PMID25824304
PMCPMC4591075
OpenAlexW2052091534

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.