ArticleAntimicrobial agents and chemotherapy2015
Efflux as a glutaraldehyde resistance mechanism in Pseudomonas fluorescens and Pseudomonas aeruginosa biofilms.
Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Pooled it
- Improving biocide evaluation using propidium monoazide (PMA) viability staining technique.Scientific reports · 2025Article
- Disinfectant-induced bacterial resistance and antibiotic cross-resistance-mechanisms and clinical relevance.Clinical and experimental medicine · 2025Review
- Activation of theInfection and immunity · 2025Article
- Chlorpromazine, impregnated in foley catheter fragments, as an antibiofilm agent to control urinary tract infections.Future microbiology · 2025Article
- Nanoplastics-mediated physiologic and genomic responses in pathogenic Escherichia coli O157:H7.Journal of nanobiotechnology · 2025Article
- Rice bacterial leaf blight drives rhizosphere microbial assembly and function adaptation.Microbiology spectrum · 2023Article
- Priming with biocides: A pathway to antibiotic resistance?Journal of applied microbiology · 2022Article
- Comparative Analysis of the Mechanism of Resistance to Silver Nanoparticles and the Biocide 2,2-Dibromo-3-Nitrilopropionamide.Antimicrobial agents and chemotherapy · 2022Article
- Prevalence of resistance genes to biocides in antibiotic-resistant Pseudomonas aeruginosa clinical isolates.Molecular biology reports · 2022Article
- Draft Genome Sequencing of Three Glutaraldehyde-Tolerant Bacteria from Produced Water from Hydraulic Fracturing.Microbiology resource announcements · 2022Article
- The impact of bacterial diversity on resistance to biocides in oilfields.Scientific reports · 2021Article
- Sulphate-reducing bacterial community structure from produced water of the Periquito and Galo de Campina onshore oilfields in Brazil.Scientific reports · 2021Article
- Long-Term Biocide Efficacy and Its Effect on a Souring Microbial Community.Applied and environmental microbiology · 2021Article
- A Critical Review of Disinfection Processes to Control SARS-CoV-2 Transmission in the Food Industry.Foods (Basel, Switzerland) · 2021Review
- Tolerance to Glutaraldehyde inFrontiers in microbiology · 2021Article
- Metagenomic Analysis of Biocide-Treated Neotropical Oil Reservoir Water Unveils Microdiversity of ThermophileFrontiers in microbiology · 2021Article
- Acquisition Risk Factors of the SCCAntibiotics (Basel, Switzerland) · 2020Article
- Carbon steel corrosion by bacteria from failed seal rings at an offshore facility.Scientific reports · 2020Article
- Nutrient Level Determines Biofilm Characteristics and Subsequent Impact on Microbial Corrosion and Biocide Effectiveness.Applied and environmental microbiology · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A major challenge in microbial biofilm control is biocide resistance. Phenotypic adaptations and physical protective effects have been historically thought to be the primary mechanisms for glutaraldehyde resistance in bacterial biofilms. Recent studies indicate the presence of genetic mechanisms for glutaraldehyde resistance, but very little is known about the contributory genetic factors. Here, we demonstrate that efflux pumps contribute to glutaraldehyde resistance in Pseudomonas fluorescens and Pseudomonas aeruginosa biofilms. The RNA-seq data show that efflux pumps and phosphonate degradation, lipid biosynthesis, and polyamine biosynthesis metabolic pathways were induced upon glutaraldehyde exposure. Furthermore, chemical inhibition of efflux pumps potentiates glutaraldehyde activity, suggesting that efflux activity contributes to glutaraldehyde resistance. Additionally, induction of known modulators of biofilm formation, including phosphonate degradation, lipid biosynthesis, and polyamine biosynthesis, may contribute to biofilm resistance and resilience. Fundamental understanding of the genetic mechanism of biocide resistance is critical for the optimization of biocide use and development of novel disinfection strategies. Our results reveal genetic components involved in glutaraldehyde resistance and a potential strategy for improved control of biofilms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.