Evidence map›Paper›PMID 25824140›Full record

ArticleStem cells translational medicine2015

Intra-articular transplantation of atsttrin-transduced mesenchymal stem cells ameliorate osteoarthritis development.

Qingqing Xia, Shouan Zhu, Yan Wu, Jiaqiu Wang, Youzhi Cai, Pengfei Chen, Jie Li, Boon Chin Heng, Hong Wei Ouyang, Ping Lu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Review
  5. Combination treatment with interferon-γ may be a potential strategy to improve the efficacy of cytotherapy for rheumatoid arthritis: A network meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024
    Review
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  13. Serum progranulin to TNF-α ratio in patients with gonarthrosis.Acta orthopaedica et traumatologica turcica · 2021
    Article
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  18. Atsttrin Promotes Cartilage Repair Primarily Through TNFR2-Akt Pathway.Frontiers in cell and developmental biology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Qingqing XiaCenter for Stem Cells and Tissue Engineering, School of Medicine, Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine, School of Medicine, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Department of Orthopedics, the First Affiliated Hospital, College of Medicine, and College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China; Department of Biosystems Science & Engineering, ETH-Zurich, Basel, Switzerland.
Shouan ZhuCenter for Stem Cells and Tissue Engineering, School of Medicine, Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine, School of Medicine, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Department of Orthopedics, the First Affiliated Hospital, College of Medicine, and College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China; Department of Biosystems Science & Engineering, ETH-Zurich, Basel, Switzerland.
Yan WuCenter for Stem Cells and Tissue Engineering, School of Medicine, Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine, School of Medicine, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Department of Orthopedics, the First Affiliated Hospital, College of Medicine, and College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China; Department of Biosystems Science & Engineering, ETH-Zurich, Basel, Switzerland.
Jiaqiu WangCenter for Stem Cells and Tissue Engineering, School of Medicine, Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine, School of Medicine, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Department of Orthopedics, the First Affiliated Hospital, College of Medicine, and College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China; Department of Biosystems Science & Engineering, ETH-Zurich, Basel, Switzerland.
Youzhi CaiCenter for Stem Cells and Tissue Engineering, School of Medicine, Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine, School of Medicine, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Department of Orthopedics, the First Affiliated Hospital, College of Medicine, and College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China; Department of Biosystems Science & Engineering, ETH-Zurich, Basel, Switzerland.
Pengfei ChenCenter for Stem Cells and Tissue Engineering, School of Medicine, Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine, School of Medicine, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Department of Orthopedics, the First Affiliated Hospital, College of Medicine, and College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China; Department of Biosystems Science & Engineering, ETH-Zurich, Basel, Switzerland.
Jie LiCenter for Stem Cells and Tissue Engineering, School of Medicine, Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine, School of Medicine, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Department of Orthopedics, the First Affiliated Hospital, College of Medicine, and College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China; Department of Biosystems Science & Engineering, ETH-Zurich, Basel, Switzerland.
Boon Chin HengCenter for Stem Cells and Tissue Engineering, School of Medicine, Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine, School of Medicine, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Department of Orthopedics, the First Affiliated Hospital, College of Medicine, and College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China; Department of Biosystems Science & Engineering, ETH-Zurich, Basel, Switzerland.
Hong Wei OuyangCenter for Stem Cells and Tissue Engineering, School of Medicine, Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine, School of Medicine, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Department of Orthopedics, the First Affiliated Hospital, College of Medicine, and College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China; Department of Biosystems Science & Engineering, ETH-Zurich, Basel, Switzerland hwoy@zju.edu.cn lupingzju@zju.edu.cn.
Ping LuCenter for Stem Cells and Tissue Engineering, School of Medicine, Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine, School of Medicine, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Department of Orthopedics, the First Affiliated Hospital, College of Medicine, and College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China; Department of Biosystems Science & Engineering, ETH-Zurich, Basel, Switzerland hwoy@zju.edu.cn lupingzju@zju.edu.cn.
Zhejiang University · CNETH Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) remains an intractable clinical challenge. Few drugs are available for reversing this degenerative disease, although some promising candidates have performed well in preclinical studies. Tumor necrosis factor α (TNFα) has been identified as a crucial effector modulating OA pathogenesis. This study aimed to investigate the therapeutic effects of Atsttrin, a novel TNFα blocker, on OA treatment. We developed genetically modified mesenchymal stem cells (MSCs) that expressed recombinant Atsttrin (named as MSC-Atsttrin). Expression levels of ADAMTS-5, MMP13, and iNOS of human chondrocytes were analyzed when cocultured with MSC-GFP/Atsttrin. OA animal models were induced by anterior cruciate ligament transection, and MSC-GFP/Atsttrin were injected into the articular cavity 1 week postsurgery. The results showed that MSC-Atsttrin significantly suppressed TNFα-driven up-regulation of matrix proteases and inflammatory factors. Intra-articular injection of MSC-Atsttrin prevented the progression of degenerative changes in the surgically induced OA mouse model. Additionally, levels of detrimental matrix hydrolases were significantly diminished. Compared with nontreated OA samples at 8 weeks postsurgery, the percentages of MMP13- and ADAMTS-5-positive cells were significantly reduced from 91.33% ± 9.87% to 24.33% ± 5.7% (p < .001) and from 91.33% ± 7.1% to 16.67% ± 3.1% (p < .001), respectively. Our results thus indicated that suppression of TNFα activity is an effective strategy for OA treatment and that intra-articular injection of MSCs-Atsttrin could be a promising therapeutic modality.

Indexed as

Cell- and Tissue-Based TherapyMesenchymal Stem Cell TransplantationAnimalsChondrocytesCoculture TechniquesDisease Models, AnimalGene Expression RegulationHumansInjections, Intra-ArticularMiceOsteoarthritisRecombinant Fusion ProteinsTumor Necrosis Factor-alphaAtsttrin fusion proteinRecombinant Fusion ProteinsTumor Necrosis Factor-alphaAtsttrinCocultureMesenchymal stem cellsOsteoarthritisTNFα

Identifiers

PMID25824140
PMCPMC4414219
OpenAlexW2128382795

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.