Evidence map›Paper›PMID 25824100›Full record

ArticleOrganic letters2015

Efficient isocyanide-less isocyanide-based multicomponent reactions.

Constantinos G Neochoritis, Silvia Stotani, Bhupendra Mishra, Alexander Dömling

Abstract read
In one paragraph

Article in Organic letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. Ugi Four-Component Reactions Using Alternative Reactants.Molecules (Basel, Switzerland) · 2023
    Review
  4. Article
  5. Synthesis of NACS omega · 2021
    Article
  6. Article
  7. Article
  8. Article
  9. MCR Scaffolds Get Hotter withMolecules (Basel, Switzerland) · 2019
    Article
  10. Review
  11. Structure and Reactivity of Glycosyl Isocyanides.European journal of organic chemistry · 2019
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. With unprotected amino acids to tetrazolo peptidomimetics.Chemical communications (Cambridge, England) · 2017
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Constantinos G NeochoritisUniversity of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Silvia StotaniUniversity of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Bhupendra MishraUniversity of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Alexander DömlingUniversity of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.

Funding

Real-time discovery of inhibitors among billion compounds for preview and downloadR01GM097082 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAMACHO, CARLOS J. · 2011 to 2020
$2.5M
NIGMS NIH HHS 1R01GM097082-01NIGMS NIH HHS R01 GM097082
6 · The paper itself

Abstract

Isocyanides are the "Jekyll and Hyde" of organic chemistry allowing for extremely interesting transformations that are not only extremely odorous but also noxious. Therefore, an isocyanide-less isocyanide-based multicomponent reaction (IMCR) has been developed, and this protocol is expected to replace many of the old procedures in the future not only in IMCR but in other areas of organic chemistry as well.

Indexed as

CyanidesMolecular StructureCyanides

Identifiers

PMID25824100
PMCPMC4733495

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.