ReviewCurrent microbiology2015
Ecologically driven competence for exogenous DNA uptake in yeast.
Review in Current microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 4 citations in OpenAlex.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unlike prokaryotes, eukaryotic organisms do not seem to be equipped with natural cell process(es) designated for exogenous DNA uptake. However, it is barely known that under laboratory circumstances resembling wild fungal environment(s), at least some lower eukaryotes could become naturally competent for exogenous DNA uptake. Thus, apart from the known fact that non-manipulated cells of yeast Saccharomyces cerevisiae take exogenous DNA by conjugation with certain bacteria, there are also mechanical and physiological mechanisms enabling their transformation under environmental conditions. This clearly shows that lower eukaryotes are amenable to transformation without applying man-made technology (i.e., naturally). However, this topic failed to raise critical scientific interest. Therefore, this review aims to scrutinize the overall implication of the phenomenon stressing its fundamental and applicable importance. It also summarizes all axiomatic laboratory circumstances/vehicles hitherto known to provoke yeast competence naturally and critically discusses plausible mechanisms behind. Possible pathways underlying the phenomenon are emphasized and a unifying model is proposed. This story potentially spans several different research fields, from evolutionary genetics to genetic transformation technology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.