ReviewClinical medicine (London, England)2015
Vitamin B12 deficiency - A 21st century perspective .
Review in Clinical medicine (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
134 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Health and Environmental Impacts, Safety, and Affordability of the EAT-Lancet Planetary Health Diet: A Multidisciplinary Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2026Pooled it
- The role of vitamin B12 in viral infections: a comprehensive review of its relationship with the muscle-gut-brain axis and implications for SARS-CoV-2 infection.Nutrition reviews · 2022Pooled it
- Impact of Beef and Beef Product Intake on Cognition in Children and Young Adults: A Systematic Review.Nutrients · 2019Pooled it
- Physiological effects of spirulina supplementation during lactate threshold exercise at simulated altitude (2,500 m): a randomized controlled trial.Journal of the International Society of Sports Nutrition · 2025Trial
- Trial
- Effect of Vitamin B12 Injection on the Vocal Performance of Professional Singers: A Randomized, Double-blind, Placebo-Controlled, Crossover Trial.JAMA otolaryngology-- head & neck surgery · 2021Trial
- Analysis of clinical pharmacist interventions in the neurology unit of a Brazilian tertiary teaching hospital.PloS one · 2019Trial
- U-Shaped Association Between Serum Vitamin B12 and All-Cause Mortality in Adults With Obesity in the United States: A Prospective Cohort Study.Current therapeutic research, clinical and experimental · 2026Article
- Oral vitamin B₁₂ after total gastrectomy for gastric cancer: mapping the evidence.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Review
- How Nutrient Deficiencies Impact the Oral Mucosa and How to Manage Them: A Narrative Review.Nutrients · 2026Review
- Vitamin B12 Deficiency Without Anemia Presenting With Delayed Orthostatic Hypotension in an Adolescent: A Case Report.Clinical case reports · 2026Article
- Choline and Its Companions: Inter-Related Roles of Choline and B Vitamins in Fetal Development and Offspring Health.Nutrients · 2026Review
- Pernicious Anemia: Basic Pathophysiology and Diagnostic Challenges in Neuropsychiatric Patients.Hematology reports · 2026Review
- Sensory Ataxia Mimicking Diabetic Neuropathy in a Long-Term Metformin User: A Case Report From Korea.Cureus · 2026Article
- Pain and IBD: The Contributing Role of Diet and Nutrition.Digestive diseases and sciences · 2026Review
- Serum vitamin B12 levels and 90-day outcomes in hospitalized patients with dementia: A cohort study.Medicine · 2026Article
- Effect of preoperative vitamin B12 levels on postoperative outcomes in CABG patients.Turk gogus kalp damar cerrahisi dergisi · 2026Article
- Addressing Vitamin BCommunications biology · 2026Article
- Effect of vitamin B12 replacement therapy in patients with premature ejaculation with B12 deficiency.BMC urology · 2026Article
- Vitamin B12 and Reproductive Health: Clinical Insights, Emerging Mechanistic Understanding, and Nutritional Aspects.Molecular reproduction and development · 2026Review
74 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on byResponse.2015
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin B12 deficiency is a common condition which can present with non-specific clinical features, and in severe cases with neurological or haematological abnormalities. Although classically caused by pernicious anaemia, this condition now accounts for a minority of cases and vitamin B12 deficiency occurs most often due to food-bound cobalamin malabsorption. Since missing the diagnosis can result in potentially severe complications, including degeneration of the spinal cord and pancytopaenia, vitamin B12 deficiency must be diagnosed early and managed appropriately. Intramuscular injections have been the mainstay of treatment, but oral replacement therapy can be effective in many cases. There is accumulating evidence that high vitamin B12 levels (values varied from 350-1,200 pmol/l) are associated with haematological and hepatic disorders, in particular with malignancy. This review focuses on the developments in the clinical features and management of vitamin B12 deficiency over the last decade.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.