ReviewSeminars in fetal & neonatal medicine2015
Predictive monitoring for sepsis and necrotizing enterocolitis to prevent shock.
Review in Seminars in fetal & neonatal medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 72 citations in OpenAlex.
- Temporal trends in heart rate characteristic index preceding necrotizing enterocolitis in preterm infants.Journal of neonatal-perinatal medicine · 2026Article
- Article
- Definitions and monitoring methods for apnea in preterm infants: a scoping review.Pediatric research · 2026Article
- Rapid Detection of Inter-alpha Inhibitor Proteins in Neonatal Sepsis and Necrotizing Enterocolitis.medRxiv : the preprint server for health sciences · 2026Article
- Portal venous gas value in predicting surgical necrotizing enterocolitis.Pediatric research · 2025Article
- Heart rate characteristics predict risk of mortality in preterm infants in low and high target oxygen saturation ranges.ERJ open research · 2024Article
- Framework for Considering Abnormal Heart Rate Characteristics and Other Signs of Sepsis in Very Low Birth Weight Infants.American journal of perinatology · 2024Article
- Inflammatory biomarkers and physiomarkers of late-onset sepsis and necrotizing enterocolitis in premature infants.Frontiers in pediatrics · 2024Article
- Efficacy of peritoneal drainage in very-low-birth-weight neonates with Bell's stage II necrotizing enterocolitis: A single-center retrospective study.World journal of gastrointestinal surgery · 2023Article
- Cardiorespiratory signature of neonatal sepsis: development and validation of prediction models in 3 NICUs.Pediatric research · 2023Article
- Preterm sepsis is associated with acute lung injury as measured by pulmonary severity score.Pediatric research · 2023Article
- Neurodevelopmental outcome of infants who develop necrotizing enterocolitis: The gut-brain axis.Seminars in perinatology · 2023Article
- Recent advances in our understanding of NEC diagnosis, prognosis and surgical approach.Frontiers in pediatrics · 2023Review
- Artificial and human intelligence for early identification of neonatal sepsis.Pediatric research · 2023Review
- Enteral Feeding and Antibiotic Treatment Do Not Influence Increased Coefficient of Variation of Total Fecal Bile Acids in Necrotizing Enterocolitis.Newborn (Clarksville, Md.) · 2023Article
- Identification of potential risk factors for the poor prognosis of neonatal sepsis.Medicine and pharmacy reports · 2022Article
- Bench to bedside - new insights into the pathogenesis of necrotizing enterocolitis.Nature reviews. Gastroenterology & hepatology · 2022Review
- Intravenous Ceftazidime-Avibactam in Extremely Premature Neonates With Carbapenem-Resistant Enterobacteriaceae: Two Case Reports.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Vital signs as physiomarkers of neonatal sepsis.Pediatric research · 2022Review
- Cost-effectiveness analysis of heart rate characteristics monitoring to improve survival for very low birth weight infants.Frontiers in health services · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Despite vigilant clinical assessment of infants in the neonatal intensive care unit (NICU), diagnosis of sepsis and necrotizing enterocolitis often does not occur until an infant has significant hemodynamic compromise. Predictive monitoring involves analysis of vital signs and other clinical data to identify infants at highest risk and to detect early-stage illness, leading to timelier treatment and improved outcomes. The first vital-sign predictive monitoring device developed for sepsis detection in babies in the NICU is the heart rate characteristics index (HeRO) monitor, which continuously analyzes the electrocardiogram signal for low heart rate variability and transient decelerations. Use of this monitor in very low birth weight infants (<1500 g) was shown in a large multicenter randomized clinical trial to significantly reduce mortality. The purpose of this review is (1) to summarize the physiologic changes in neonatal sepsis and progression to shock, (2) to review efforts toward risk stratification for sepsis shortly after birth based on demographic and physiologic scoring systems, (3) to describe development and implementation of heart rate characteristics monitoring and other important aspects of sepsis early warning systems, and (4) to provide an overview of current research analyzing multiple vital signs and other clinical variables in an attempt to develop even more effective predictive monitoring devices and systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.