ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015
Dwelling quietly in the rich club: brain network determinants of slow cortical fluctuations.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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92 citing papers in PubMed.
- Competitive interactions shape mammalian brain network dynamics and computation.Nature neuroscience · 2026Article
- Exploring the Role of the Rich Club in Network Control of Neurocognitive States.Human brain mapping · 2026Article
- The biological role of local and global fMRI BOLD signal variability in multiscale human brain organization.Nature communications · 2026Article
- Neural mechanisms of feature binding in working memory.Communications biology · 2026Article
- MRI assessment of intrinsic neural timescales in male alcohol use disorder patients.Frontiers in psychiatry · 2026Article
- Criticality and increased intrinsic neural timescales in stroke.NPJ systems biology and applications · 2025Article
- From Chaos to Coherence: Effects of High-Order Synaptic Correlations on Neural Dynamics.ArXiv · 2025Article
- Spectral imprint of structural embedding in effective connectivity.bioRxiv : the preprint server for biology · 2025Article
- Network Mechanisms Underlying the Regional Diversity of Variance and Time Scales of the Brain's Spontaneous Activity Fluctuations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Mapping and modeling age-related changes in intrinsic neural timescales.Communications biology · 2025Article
- Multiple-timescale dynamics, mixed mode oscillations and mixed affective states in a model of bipolar disorder.Cognitive neurodynamics · 2024Article
- Network-Assisted Mediation Analysis with High-Dimensional Neuroimaging Mediators.Proceedings of machine learning research · 2024Article
- The significance of structural rich club hubs for the processing of hierarchical stimuli.Human brain mapping · 2024Article
- Cortical timescales and the modular organization of structural and functional brain networks.Human brain mapping · 2024Article
- Dendrites contribute to the gradient of intrinsic timescales encompassing cortical and subcortical brain networks.Frontiers in cellular neuroscience · 2024Article
- Towards a biologically annotated brain connectome.Nature reviews. Neuroscience · 2023Review
- Inter-subject correlation during long narratives reveals widespread neural correlates of reading ability.NeuroImage · 2023Article
- Abnormal and Changing Information Interaction in Adults with Attention-Deficit/Hyperactivity Disorder Based on Network Motifs.Brain sciences · 2023Article
- A Dynamical Systems Approach to Characterizing Brain-Body Interactions during Movement: Challenges, Interpretations, and Recommendations.Sensors (Basel, Switzerland) · 2023Review
- Review
32 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
For more than a century, cerebral cartography has been driven by investigations of structural and morphological properties of the brain across spatial scales and the temporal/functional phenomena that emerge from these underlying features. The next era of brain mapping will be driven by studies that consider both of these components of brain organization simultaneously--elucidating their interactions and dependencies. Using this guiding principle, we explored the origin of slowly fluctuating patterns of synchronization within the topological core of brain regions known as the rich club, implicated in the regulation of mood and introspection. We find that a constellation of densely interconnected regions that constitute the rich club (including the anterior insula, amygdala and precuneus) play a central role in promoting a stable, dynamical core of spontaneous activity in the primate cortex. The slow timescales are well matched to the regulation of internal visceral states, corresponding to the somatic correlates of mood and anxiety. In contrast, the topology of the surrounding 'feeder' cortical regions shows unstable, rapidly fluctuating dynamics likely to be crucial for fast perceptual processes. We discuss these findings in relation to psychiatric disorders and the future of connectomics.
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