Evidence map›Paper›PMID 25823863›Full record

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015

The BRAIN Initiative: developing technology to catalyse neuroscience discovery.

Lyric A Jorgenson, William T Newsome, David J Anderson, Cornelia I Bargmann, Emery N Brown, Karl Deisseroth, John P Donoghue, Kathy L Hudson, Geoffrey S F Ling, Peter R MacLeish and 9 more

Abstract readReview
In one paragraph

Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Neurodatascience: Past, Present, and Future.Data science in science · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Whole-brain causal discovery using fMRI.Network neuroscience (Cambridge, Mass.) · 2025
    Article
  10. Review
  11. Article
  12. The Problem-Ladenness of Theory.Computational brain & behavior · 2024
    Article
  13. A Perspective on Neuroscience Data Standardization with Neurodata Without Borders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Data science and its future in large neuroscience collaborations.bioRxiv : the preprint server for biology · 2024
    Article
  20. Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Lyric A JorgensonOffice of the Director, National Institutes of Health, Bethesda, MD 20892, USA jorgensonla@od.nih.gov.
William T NewsomeHoward Hughes Medical Institute and Stanford Neurosciences Institute, Stanford University, Stanford, CA 94305, USA bnewsome@stanford.edu.
David J AndersonHoward Hughes Medical Institute and Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Cornelia I BargmannHoward Hughes Medical Institute and Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, NY 10065, USA.
Emery N BrownInstitute for Medical Engineering and Science and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114, USA.
Karl DeisserothHoward Hughes Medical Institute and Department of Bioengineering, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
John P DonoghueBrown Institute for Brain Science, Brown University, Providence, RI 02912, USA.
Kathy L HudsonOffice of the Director, National Institutes of Health, Bethesda, MD 20892, USA.
Geoffrey S F LingBiological Technologies Office, Defense Advanced Research Projects Agency, Arlington, VA 22203, USA.
Peter R MacLeishDepartment of Neurobiology, Neuroscience Institute, Morehouse, School of Medicine, Atlanta, GA 30310, USA.
Eve MarderBiology Department and Volen Center, Brandeis University, Waltham, MA 02454, USA.
Richard A NormannDepartment of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA.
Joshua R SanesDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Mark J SchnitzerHoward Hughes Medical Institute and James H. Clark Center for Biomedical Engineering & Sciences, CNC Program, Stanford University, Stanford, CA 94305, USA.
Terrence J SejnowskiHoward Hughes Medical Institute and Computational Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
David W TankPrinceton Neuroscience Institute, Bezos Center for Neural Circuit Dynamics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Roger Y TsienHoward Hughes Medical Institute and Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA.
Kamil UgurbilCenter for Magnetic Resonance Research, University of Minnesota, MN 55454, USA.
John C WingfieldDirectorate for Biological Sciences, National Science Foundation, Arlington, VA 22230, USA.

Funding

CLARITY: fully-assembled biologyR01MH099647 · NIMH · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2012 to 2016
$23.0M
Structural and molecular identification of circuitry underlying joint processing of motivation and aversionR37DA035377 · NIDA · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2013 to 2022
$6.2M
DYNAMICS OF SIGNAL TRANSDUCTION IN NEURONSR01NS027177 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ADAMS, STEPHEN ROY, ELLISMAN, MARK H · 1989 to 2017
$5.8M
Technology development for fast optical interrogation of living neural circuitryR01MH075957 · NIMH · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2008 to 2012
$2.6M
Howard Hughes Medical InstituteNIDA NIH HHS R37 DA035377NIMH NIH HHS R01 MH075957NIMH NIH HHS R01 MH099647NINDS NIH HHS R01 NS027177
6 · The paper itself

Abstract

The evolution of the field of neuroscience has been propelled by the advent of novel technological capabilities, and the pace at which these capabilities are being developed has accelerated dramatically in the past decade. Capitalizing on this momentum, the United States launched the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative to develop and apply new tools and technologies for revolutionizing our understanding of the brain. In this article, we review the scientific vision for this initiative set forth by the National Institutes of Health and discuss its implications for the future of neuroscience research. Particular emphasis is given to its potential impact on the mapping and study of neural circuits, and how this knowledge will transform our understanding of the complexity of the human brain and its diverse array of behaviours, perceptions, thoughts and emotions.

Indexed as

Brain MappingHumansNerve NetNeurosciencesResearch DesignBRAIN Initiativeneural circuitryneurotechnology

Identifiers

PMID25823863
PMCPMC4387507

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.