ArticleSpinal cord2015
3D angioarchitecture changes after spinal cord injury in rats using synchrotron radiation phase-contrast tomography.
Article in Spinal cord, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Review
- A combinatorial method to visualize the neuronal network in the mouse spinal cord: combination of a modified Golgi-Cox method and synchrotron radiation micro-computed tomography.Histochemistry and cell biology · 2021Article
- The spatiotemporal spread of cervical spinal cord contusion injury pathology revealed by 3D in-line phase contrast synchrotron X-ray microtomography.Experimental neurology · 2021Article
- Innovative high-resolution microCT imaging of animal brain vasculature.Brain structure & function · 2020Article
- Three-dimensional visualization of microvasculature from few-projection data using a novel CT reconstruction algorithm for propagation-based X-ray phase-contrast imaging.Biomedical optics express · 2020Article
- Non-destructive 3D Microtomography of Cerebral Angioarchitecture Changes Following Ischemic Stroke in Rats Using Synchrotron Radiation.Frontiers in neuroanatomy · 2019Article
- Optimising complementary soft tissue synchrotron X-ray microtomography for reversibly-stained central nervous system samples.Scientific reports · 2018Article
- 3D visualization of the lumbar facet joint after degeneration using propagation phase contrast micro-tomography.Scientific reports · 2016Article
- Therapeutic Hypothermia in Spinal Cord Injury: The Status of Its Use and Open Questions.International journal of molecular sciences · 2015Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designA basic experiment study.
objectivesAn understanding of the three-dimensional (3D) angioarchitecture changes that occur after SCI will improve our knowledge of the pathogenesis of SCI and aid in the development of valuable therapeutic strategies to improve its poor outcomes. Our aim was to visualize the normal and traumatized spinal angioarchitecture in 3D using a high-resolution synchrotron radiation phase-contrast tomography (SR-PCT) and evaluate its diagnostic capability.
settingSCI Center of Xiangya Hospital of Central South University in China.
methodsSR-PCT was used as novel high-resolution imaging tool to detect 3D morphological alterations in spinal cord microvasculature after injury.
resultsIn a rat model, the morphology of the microvasculature on 2D digital slices was matched with histological findings in both the normal and injured spinal cord. 3D angioarchitecture changes after SCI were successfully obtained via SR-PCT without the use of a contrast agent. Quantitative analysis on 3D images of the injured spinal cord revealed a significant decrease in the number and volume of vascular networks. This was especially relevant to vessels with a diameter <50 μm.
conclusionThe 3D local blood supply to the spinal cord was severely disrupted after the acute violent injury. Our results indicate that the use of SR-PCT may improve our understanding of the pathogenesis of SCI and provide a new approach to the morphological investigation of neurovascular diseases in preclinical research.
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