ArticleDevelopmental biology2015
Xenopus: An in vivo model for imaging the inflammatory response following injury and bacterial infection.
Article in Developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Putative muscle stem cells promoteProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Intracytoplasmic Sperm Injection Using 20-Year-Old Cryopreserved Sperm Results in Normal, Viable, and Reproductive Offspring inAnimals : an open access journal from MDPI · 2025Article
- The contribution of amphibian macrophage subsets to scarless regeneration of skin wounds.Frontiers in immunology · 2025Article
- Exploring the Role of a Putative Secondary Metabolite Biosynthesis Pathway inMicroorganisms · 2024Article
- Macrophages modulate fibrosis during newt lens regeneration.Stem cell research & therapy · 2024Article
- An improved method for whole-mountFrontiers in cell and developmental biology · 2024Article
- Macrophages modulate fibrosis during newt lens regeneration.Research square · 2023Article
- regeneration factors expressed on myeloid expression in macrophage-like cells is required for tail regeneration in Xenopus laevis tadpoles.Development (Cambridge, England) · 2023Article
- Review
- Epigenetic regulation of GABAergic differentiation in the developing brain.Frontiers in cellular neuroscience · 2022Article
- Article
- The myeloid lineage is required for the emergence of a regeneration-permissive environment followingDevelopment (Cambridge, England) · 2020Article
- Comparative Transcriptome Analysis of the Regenerating Zebrafish Telencephalon Unravels a Resource With Key Pathways During Two Early Stages and Activation of Wnt/β-Catenin Signaling at the Early Wound Healing Stage.Frontiers in cell and developmental biology · 2020Article
- An in vivo brain-bacteria interface: the developing brain as a key regulator of innate immunity.NPJ Regenerative medicine · 2020Article
- Adoptive Transfer of Fluorescently Labeled Immune Cells inCold Spring Harbor protocols · 2019Article
- A Xenopus tadpole alternative model to study innate-like T cell-mediated anti-mycobacterial immunity.Developmental and comparative immunology · 2019Review
- Epithelial-Mesenchymal Transition Promotes the Differentiation Potential ofStem cells international · 2019Article
- More Than Just a Bandage: Closing the Gap Between Injury and Appendage Regeneration.Frontiers in physiology · 2019Review
- Learning from regeneration research organisms: The circuitous road to scar free wound healing.Developmental biology · 2018Review
- Discovering Macrophage Functions UsingFrontiers in immunology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
A major goal in regenerative medicine is to identify therapies to facilitate our body׳s innate abilities to repair and regenerate following injury, disease or aging. In the past decade it has become apparent that the innate immune system is able to affect the speed and quality of the regenerative response through mechanisms that are not entirely clear. For this reason there has been a resurgent interest in investigating the role of inflammation during tissue repair and regeneration. Remarkably, there have only been a handful of such studies using organisms with high regenerative capacity. Here we perform a study of the inflammatory response following injury in Xenopus larvae, which are able to achieve scarless wound healing and to regenerate appendages, as a preamble into understanding the role that inflammation plays during tissue repair and regeneration in this organism. We characterized the morphology and migratory behavior of granulocytes and macrophages following sterile and infected wounding regimes, using various transgenic lines that labeled different types of myeloid lineages, including granulocytes and macrophages. Using this approach we found that the inflammatory response following injury and infection in Xenopus larvae is very similar to that seen in humans, suggesting that this model provides an easily tractable and medically relevant system to investigate inflammation following injury and infection in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.