ArticleNature communications2015
Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia.
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Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.
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54citing papers in PubMed, 4 pooled it
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Who cites it
54 citing papers in PubMed, 4 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Proteome-wide Mendelian randomisation identifies causal links between blood proteins and myopia.Journal of global health · 2026Pooled it
- Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia.Nature genetics · 2020Pooled it
- Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error.Communications biology · 2020Pooled it
- Novel evidence for complement system activation in chick myopia and hyperopia models: a meta-analysis of transcriptome datasets.Scientific reports · 2017Pooled it
- Genome-wide association study for refractive error imputed from fundus images via deep learning: a proof-of-concept study.Japanese journal of ophthalmology · 2026Article
- The Association between Saccadic Eye Movement Parameters and Mild Cognitive Impairment: The Nagahama Study.Ophthalmology science · 2026Article
- Genome-Wide Meta-Analysis for High Myopia Provides Insights into Disease Mechanisms and Reveals a Causal Link to Primary Open-Angle Glaucoma.Ophthalmology science · 2026Article
- Replication of the Association between Retinal Aging Clock Susceptibility Genes and Retinal Age Gap in an Asian Population: The Nagahama Study.Ophthalmology science · 2026Article
- Genome-wide association study of quantitative ocular traits, including axial length and central corneal thickness, identifies loci for refractive error in the Korean population.Genes & genomics · 2026Article
- Potential Negative Feedback between Age and Baseline Axial Length on Axial Elongation in High Myopia.Ophthalmology science · 2026Article
- Decreased scleral Wnt5aNature communications · 2025Article
- Article
- A genome-wide association between foveal thickness and arrhythmia.Communications medicine · 2025Article
- Bidirectional Phosphorylation Changes in Opsins Associated With Early Myopia and Hyperopia Signal Regulation by Phosphoproteomics.Investigative ophthalmology & visual science · 2025Article
- Association between the retinal age gap and systemic diseases in the Japanese population: the Nagahama study.Japanese journal of ophthalmology · 2025Article
- Regulatory Effects of the Wnt7b/β-Catenin/MMP-2 Signaling Pathway on Scleral Stiffness in Guinea Pigs With Form-Deprivation Myopia.Investigative ophthalmology & visual science · 2025Article
- Identification of LRRC46 as a novel candidate gene for high myopia.Science China. Life sciences · 2024Article
- The Role of Retinal Dysfunction in Myopia Development.Cellular and molecular neurobiology · 2023Review
- A Genome-Wide Association Study for Susceptibility to Axial Length in Highly Myopic Eyes.Phenomics (Cham, Switzerland) · 2023Article
- A multiethnic genome-wide analysis of 19,420 individuals identifies novel loci associated with axial length and shared genetic influences with refractive error and myopia.Frontiers in genetics · 2023Article
Corrections and comments
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Authors and funding
47 authors at 14 institutions in 8 countries.
Masahiro MiyakeDepartment of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
Kenji YamashiroDepartment of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.ORCID http://orcid.org/0000-0001-9354-8558
Yasuharu TabaraCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 6068503, Japan.
Kenji SudaDepartment of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
Satoshi MorookaDepartment of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
Hideo NakanishiDepartment of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
Chiea-Chuen KhorSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore.
Peng ChenSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore.
Fan QiaoSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore.
Isao NakataDepartment of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
Yumiko Akagi-KurashigeDepartment of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
Norimoto GotohCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 6068503, Japan.
Akitaka TsujikawaDepartment of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
Akira MeguroDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama 2360027, Japan.
Sentaro KusuharaDivision of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe 6570013, Japan.
Ozen PolasekFaculty of Medicine, University of Split, Split 21000, Croatia.
Caroline HaywardMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH8 9YL, UK.
Alan F WrightMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH8 9YL, UK.
Harry CampbellCentre for Population Health Sciences, Medical School, Teviot, Edinburgh EH8 9AG, UK.
Andrea J RichardsonCentre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria 3002, Australia.
Maria SchacheCentre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria 3002, Australia.
Masaki TakeuchiDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama 2360027, Japan.
David A MackeyCentre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria 3002, Australia.
Alex W HewittCentre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria 3002, Australia.
Gabriel CuellarStatistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Yi ShiSichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, China.
Luling HuangSichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, China.
Zhenglin YangSichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, China.
Kim Hung LeungDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong SAR 99907, China.
Patrick Y P KaoCentre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong SAR 99907, China.
Maurice K H YapCentre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong SAR 99907, China.
Shea Ping YipDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong SAR 99907, China.ORCID http://orcid.org/0000-0002-2170-8185
Muka MoriyamaDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo 1130034, Japan.
Kyoko Ohno-MatsuiDepartment of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo 1130034, Japan.
Nobuhisa MizukiDepartment of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama 2360027, Japan.
Stuart MacGregorStatistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
Veronique VitartMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH8 9YL, UK.
Tin AungDepartment of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore.
Seang-Mei SawSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore.
E-Shyong TaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore.
Tien Yin WongDepartment of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore.
Ching-Yu ChengDepartment of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore.
Paul N BairdCentre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria 3002, Australia.
Ryo YamadaCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 6068503, Japan.
Fumihiko MatsudaCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 6068503, Japan.
Nagahama Study Group
Nagahisa YoshimuraDepartment of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
Kyoto University · JPNational University of Singapore · SGHong Kong Polytechnic University · HKThe University of Melbourne · AUInstitute of Genetics and Cancer · GBTokyo Medical and Dental University · JPUniversity of Electronic Science and Technology of China · CNQIMR Berghofer Medical Research Institute · AUYokohama City University · JPGlasgow Centre for Population Health · GBKobe University · JPLions Eye Institute · AUNational Human Genome Research Institute · USUniversity of Split · HR
Funding
Medical Research Council MC_PC_U127561128
Abstract
Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta=3.9 × 10(-13)) and corneal curvature (Pmeta=2.9 × 10(-40)) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case-control study with 1,478 Asian patients and 4,689 controls (odds ratio (OR)meta=1.13, Pmeta=0.011). We also find in a mouse model of myopia downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia.
Indexed as
AdolescentAdultAnimalsAsian PeopleCohort StudiesCorneaDisease Models, AnimalFemaleGenetic Predisposition to DiseaseGenotypeHumansImmunohistochemistryMaleMiceMiddle AgedMyopiaProto-Oncogene ProteinsRNA, MessengerWNT7B protein, humanWnt7b protein, mouseWnt Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.