ReviewPflugers Archiv : European journal of physiology2015
Evolutionary dynamics of metazoan TRP channels.
Review in Pflugers Archiv : European journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Review
- Sensing Underwater: Diversifying Selection, Convergent Evolution and Inactivation in Sensory Receptors' Genes of Aquatic Mammals.Journal of molecular evolution · 2026Article
- Evolutionary adaptations of TRPA1 thermosensitivity and skin thermoregulation in vertebrates.iScience · 2025Article
- Evolution of Sensory Receptors.Annual review of cell and developmental biology · 2024Review
- The versatility of the putative transient receptor potential ion channels in regulating the calcium signaling inmSphere · 2023Article
- Thermotaxis in an apolar, non-neuronal animal.Journal of the Royal Society, Interface · 2023Article
- TRPM8 thermosensation in poikilotherms mediates both skin colour and locomotor performance responses to cold temperature.Communications biology · 2023Article
- TRPV3 and Itch: The Role of TRPV3 in Chronic Pruritus according to Clinical and Experimental Evidence.International journal of molecular sciences · 2022Review
- Phototransduction in a marine sponge provides insights into the origin of animal vision.iScience · 2022Article
- Article
- A Transient Receptor Potential-like Calcium Ion Channel in the Filamentous FungusJournal of fungi (Basel, Switzerland) · 2021Article
- Diverse sensitivities of TRPA1 from different mosquito species to thermal and chemical stimuli.Scientific reports · 2019Article
- Characterization of TRPA channels in the starfish Patiria pectinifera: involvement of thermally activated TRPA1 in thermotaxis in marine planktonic larvae.Scientific reports · 2017Article
- Isoform-specific modulation of the chemical sensitivity of conserved TRPA1 channel in the major honeybee ectoparasitic mite, Tropilaelaps mercedesae.Open biology · 2016Article
- TRPA1 Channels inFrontiers in physiology · 2016Article
- Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transient receptor potential (TRP) channels are unusual among cation channels because of their diverse cation selectivities and activation mechanisms. TRP channels thus play major roles in various sensory perceptions by functioning as multimodal signal integrators. Some TRP subfamily members are also implicated in acute and chronic pain and inflammation. So far, most TRP channel studies have been targeted to human and model organisms within a limited evolutionary context. Classification of TRP channels in various animal genomes has revealed extensive gene gain and loss events across animal species. Furthermore, the chemical activation profiles of some orthologous TRP channels were different between species such as human and mouse. Amino acid substitutions must underlie such differences, and the crucial amino acid residues have been identified in some cases. These changes represent the evolution of TRP channels at the amino acid sequence level. There is also evidence that TRP channels have obtained species-diversity through alternative splicing and possibly cis-regulatory element mutations. All of the above demonstrate the dynamic and plastic evolutionary history of metazoan TRP channels at multiple levels, possibly in conjunction with the specific habitats and life histories of individual species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.