ArticleBMJ open2015
Practice guidelines for sedation and analgesia management of critically ill children: a pilot study evaluating guideline impact and feasibility in the PICU.
Article in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Ethics and end-of-life in pediatric and neonatal ICUs: a systematic review of recommendations.BMC palliative care · 2025Pooled it
- Assessment and treatment of the withdrawal syndrome in paediatric intensive care units: Systematic review.Medicine · 2020Pooled it
- Strategies for the management and prevention of withdrawal syndrome in critically ill pediatric patients: a systematic review.Revista Brasileira de terapia intensivaPooled it
- A Neonatal Nurse-Controlled Model of Analgesia to Manage Post-Operative Pain in the Surgical Neonate: A Pilot Randomised Controlled Trial.Journal of advanced nursing · 2026Trial
- Implementation and Results of Intraoperative Methadone in Pediatric Cardiac Surgery: Early Experiences and Outcomes.World journal for pediatric & congenital heart surgery · 2026Article
- Adapting Evidence-Based Practice Guidelines for Sedation, Analgesia, Withdrawal, and Delirium Assessment and Management in Critically Ill Children.Critical care research and practice · 2026Article
- Protocolized sedation may reduce ventilation and sedation requirements in the pediatric intensive care unit: a systematic review and meta-analysis.Clinical and experimental pediatrics · 2025Article
- Cross-cultural adaptation of the State Behavioral Scale to Brazilian Portuguese.Critical care science · 2025Article
- Effectiveness, quality and implementation of pain, sedation, delirium, and iatrogenic withdrawal syndrome algorithms in pediatric intensive care: a systematic review and meta-analysis.Frontiers in pediatrics · 2023Review
- A pilot study of ADRA2A genotype association with doses of dexmedetomidine for sedation in pediatric patients.Pharmacotherapy · 2022Article
- Same baby, different care: variations in practice between neonatologists and pediatric intensivists.European journal of pediatrics · 2022Article
- Pain and sedation management and monitoring in pediatric intensive care units across Europe: an ESPNIC survey.Critical care (London, England) · 2022Article
- Implementation of a sedation protocol: a quality improvement project to enhance sedation management in the paediatric intensive care unit.BMJ open quality · 2022Article
- Sedation protocols in the pediatric intensive care unit: fact or fiction?Translational pediatrics · 2021Review
- Adult sedation and analgesia in a resource limited intensive care unit - A Systematic Review and evidence based guideline.Annals of medicine and surgery (2012) · 2021Review
- Current State of Analgesia and Sedation in the Pediatric Intensive Care Unit.Journal of clinical medicine · 2021Review
- Variability of Dosing and Number of Medications Needed to Achieve Adequate Sedation in Mechanically Ventilated Pediatric Intensive Care Patients.Clinical and translational science · 2021Article
- MONISEDA Project: Improving Analgosedation Monitoring in Spanish Pediatric Intensive Care Units.Frontiers in pediatrics · 2021Article
- Practices related to assessment of sedation, analgesia and delirium among critical care pediatricians in Brazil.Einstein (Sao Paulo, Brazil) · 2020Article
- Effectiveness of Protocolized Sedation Utilizing the COMFORT-B Scale in Mechanically Ventilated Children in a Pediatric Intensive Care Unit.Journal of pediatric intensive care · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe aim of this study was to develop and implement guidelines for sedation and analgesia management in the paediatric intensive care unit (PICU) and evaluate the impact, feasibility and acceptability of these as part of a programme of research in this area and as a prelude to future trial work.
methodThis pilot study used a pre-post design using a historical control.
settingTwo PICUs at different hospitals in an Australian metropolitan city.
participantsPatients admitted to the PICU and ventilated for ≥24 h, aged more than 1 month and not admitted for seizure management or terminal care.
interventionGuidelines for sedation and analgesia management for critically ill children including algorithm and assessment tools. OUTCOME VARIABLES: In addition to key outcome variables (ventilation time, medication dose and duration, length of stay), feasibility outcomes data (recruitment, data collection, safety) were evaluated. Guideline adherence was assessed through chart audit and staff were surveyed about merit and the use of guidelines.
resultsThe guidelines were trialled for a total of 12 months on 63 patients and variables compared with the historical control group (n=75). Analysis revealed differences in median Morphine infusion duration between groups (pretest 3.63 days (87 h) vs post-test 2.83 days (68 h), p=0.05) and maximum doses (pretest 120 μg/kg/h vs post-test 97.5 μg/kg/h) with no apparent change to ventilation duration. Chart audit revealed varied use of tools, but staff were positive about the guidelines and their use in practice.
conclusionsThe sedation guidelines impacted on the duration and dosage of agents without any apparent impact on ventilation duration or length of stay. Furthermore, the guidelines appeared to be feasible and acceptable in clinical practice. The results of the study have laid the foundation for follow-up studies in withdrawal from sedation, point prevalence and longitudinal studies of sedation practices as well as drug trial work.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.